In situ validation of VEGFR-2 and α v ß 3 integrin as targets for breast lesion characterization.

Angiogenesis
Josef EhlingFabian Kiessling

Abstract

Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, in this retrospective clinical study employing patient tissues, the diagnostic value of VEGFR-2, α v ß 3 integrin and vascular area fraction for the diagnosis and differentiation of breast neoplasia was evaluated. To this end, tissue sections of breast cancer (n = 40), pre-invasive ductal carcinoma in situ (DCIS; n = 8), fibroadenoma (n = 40), radial scar (n = 6) and normal breast tissue (n = 40) were used to quantify (1) endothelial VEGFR-2, (2) endothelial α v ß 3 integrin and (3) total α v ß 3 integrin expression, as well as (4) the vascular area fraction. Sensitivity and specificity to differentiate benign from malignant lesions were calculated for each marker by receiver operating characteristics (ROC) analyses. Whereas vessel density, as commonly used, did not significantly differ between benign and malignant lesions (AUROC: 0.54), VEGFR-2 and α v ß 3 integrin levels were gradually up-regulated in carcinoma v...Continue Reading

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Citations

Apr 6, 2018·Endocrine-related Cancer·Chen WangYansong Lin
Sep 19, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Simona TurcoMassimo Mischi
Feb 13, 2021·NPJ Breast Cancer·Sunitha BachawalKatheryne E Wilson

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