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In-solution Y-chromosome capture-enrichment on ancient DNA libraries

BMC Genomics

Aug 16, 2018

Diana I Cruz-DávalosMaría C Avila-Arcos

Abstract

As most ancient biological samples have low levels of endogenous DNA, it is advantageous to enrich for specific genomic regions prior to sequencing. One approach-in-solution capture-enrichment-retrieves sequences of interest and reduces the fraction of microbial DNA. In this work, we im...read more

Mentioned in this Paper

Y Chromosome
Laboratory Procedures
Genome
History, Ancient
Nucleic Acid Sequencing
Retrieval
Chromosomes, Human, Y
DNA Library
Ancient DNA
Whole Genome Amplification
39
33
Paper Details
References
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  • Citations2
  • References1
  • Citations2
1

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In-solution Y-chromosome capture-enrichment on ancient DNA libraries

BMC Genomics

Aug 16, 2018

Diana I Cruz-DávalosMaría C Avila-Arcos

PMID: 30107783

DOI: 10.1186/s12864-018-4945-x

Abstract

As most ancient biological samples have low levels of endogenous DNA, it is advantageous to enrich for specific genomic regions prior to sequencing. One approach-in-solution capture-enrichment-retrieves sequences of interest and reduces the fraction of microbial DNA. In this work, we im...read more

Mentioned in this Paper

Y Chromosome
Laboratory Procedures
Genome
History, Ancient
Nucleic Acid Sequencing
Retrieval
Chromosomes, Human, Y
DNA Library
Ancient DNA
Whole Genome Amplification
39
33

Similar Papers Found In These Feeds

Perturb-seq

Perturb-seq has combined CRISPR gene inactivation and single-cell rna-sequencing (scRNA-seq) and is the newest addition to the geneticist's arsenal, providing scientists with study methods for functional genomics. Discover the latest research here.

Ancient DNA

Ancient DNA sequences are able to offer valuable insights into molecular evolutionary processes, but are notoriously difficult to analyze due to molecular damage and exogenous dna contamination. Discover the latest research on Ancient DNA here.

Related Papers

American Journal of Human Genetics

Pulling out the 1%: whole-genome capture for the targeted enrichment of ancient DNA sequencing libraries

American Journal of Human GeneticsFebruary 27, 2014
Meredith L CarpenterCarlos D Bustamante
Molecular Ecology Resources

Experimental conditions improving in-solution target enrichment for ancient DNA

Molecular Ecology ResourcesAugust 28, 2016
Diana I Cruz-DávalosLudovic Orlando
Paper Details
References
  • References1
  • Citations2
  • References1
  • Citations2
1
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