Abstract
Ivermectin treatment can cause central nervous system adverse events (CNS-AEs) in persons with very high-density Loa loa microfilaremia (≥ 30,000 mf/mL blood). Hypoendemic onchocerciasis areas where L. loa is endemic have been excluded from ivermectin mass drug administration programs (MDA) because of the concern for CNS AEs. The rapid assessment procedure for L. loa (RAPLOA) is a questionnaire survey to assess history of eye worm. If ≥ 40% of respondents report eye worm, this correlates with ≥ 2% prevalence of very high-density loiasis microfilaremia, posing an unacceptable risk of CNS-AEs after MDA. In 2016, we conducted a L. loa study in 110 ivermectin-naïve, suspected onchocerciasis hypoendemic villages in southern Nigeria. In previous RAPLOA surveys these villages had prevalences between 10% and 67%. We examined 10,605 residents using the LoaScope, a cell phone-based imaging device for rapidly determining the microfilaria (mf) density of L. loa infections. The mean L. loa village mf prevalence was 6.3% (range 0-29%) and the mean individual mf count among positives was 326 mf/mL. The maximum individual mf count was only 11,429 mf/mL, and among 2,748 persons sampled from the 28 villages with ≥ 40% RAPLOA, the ≥ 2% threshold ...Continue Reading
References
Jul 5, 1997·Lancet·J GardonM Boussinesq
May 9, 1998·The American Journal of Tropical Medicine and Hygiene·M BoussinesqJ P Chippaux
Feb 21, 2004·Filaria Journal·Nana AY Twum-Danso
Feb 21, 2004·Filaria Journal·David G AddissFrank O Richards
Jun 1, 2006·Advances in Parasitology·Boakye A Boatin, Frank O Richards
Jul 22, 2009·PLoS Neglected Tropical Diseases·Lamine DiawaraJan H F Remme
Dec 10, 2009·The American Journal of Tropical Medicine and Hygiene·Joseph KamgnoMichel Boussinesq
Jun 8, 2010·Acta Tropica·Afework Hailemariam TekleUche Amazigo
Aug 31, 2010·Acta Tropica·E W CuppF Richards
Jul 9, 2011·The Korean Journal of Parasitology·A A HassanF O Owagboriaye
Jul 9, 2011·PLoS Neglected Tropical Diseases·Honorat Gustave Marie ZouréJan H F Remme
Feb 4, 2012·Parasites & Vectors·Samuel WanjiJan H Remme
Apr 25, 2014·The Lancet Infectious Diseases·Moses Katabarwa, Frank Richards
May 8, 2015·Science Translational Medicine·Michael V D'AmbrosioDaniel A Fletcher
Aug 19, 2015·Infectious Diseases of Poverty·Louise A Kelly-HopeDavid H Molyneux
Aug 5, 2017·PLoS Neglected Tropical Diseases·Jennifer R HerricksChristopher J L Murray
Nov 9, 2017·The New England Journal of Medicine·Joseph KamgnoMichel Boussinesq
Citations
May 27, 2020·PLoS Neglected Tropical Diseases·Federico GobbiZeno Bisoffi
Sep 23, 2020·The American Journal of Tropical Medicine and Hygiene·Lindsay J RakersFrank O Richards
Oct 30, 2020·Research and Reports in Tropical Medicine·Thomson LakwoDidier Bakajika
Oct 22, 2019·Diagnostic Microbiology and Infectious Disease·Oussama MouriRenaud Piarroux
Dec 10, 2020·EClinicalMedicine·Cédric B ChesnaisMichel Boussinesq
Aug 26, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Anil Kumar, Nandita Shashindran