In-stent restenosis in bare metal stents versus sirolimus-eluting stents after primary coronary intervention for acute myocardial infarction and subsequent transcoronary transplantation of autologous stem cells.

Clinical Cardiology
Clemens SteinwenderFranz Leisch

Abstract

Following stenting for acute myocardial infarction, transcoronary transplantation of granulocyte-colony stimulating factor (G-CSF) mobilized autologous stem cells (ASC) has been shown to result in an increased in-stent restenosis rate of bare metal stents (BMS). This study sought to compare the extent of neointimal growth in BMS and sirolimus-eluting stents (SES) after primary implantation, and subsequent transcoronary transplantation of G-CSF mobilized stem cells. Patients with stenting of the left anterior descending coronary artery for acute anterior myocardial infarction were randomly assigned to receive a BMS or SES. Intracoronary stem cell injection was performed after G-CSF application for at least 4 d and cell apheresis. The angiograms obtained after cell transplantation and after 6 mo were analyzed by quantitative coronary angiography. We performed primary stenting and stem cell transplantion in 16 patients who received a BMS (n = 8) or an SES (n = 8). In 2 patients with a BMS, late stent thrombosis occurred after 58 d and 177 d, respectively. In the remaining patients, control angiography after 6 mo revealed in-stent restenosis of >50% in no patients with SES but in 4 patients with BMS (67%). Late lumen loss and in-st...Continue Reading

References

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Citations

Sep 21, 2010·Cardiovascular Research·Winston ShimPhilip Wong
May 26, 2009·JACC. Cardiovascular Interventions·Giulio Guagliumi, Marco Costa
Mar 9, 2012·Cardiology Research and Practice·Duc Thang VuTheo Kofidis
Aug 24, 2017·The Cochrane Database of Systematic Reviews·Joshua FeinbergJanus C Jakobsen
May 11, 2021·Surgical Technology International·Guglielmo StefanelliLuca Weltert

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