PMID: 9159149May 27, 1997Paper

In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM

Proceedings of the National Academy of Sciences of the United States of America
L LightstoneR I Lechler

Abstract

The independent influences of invariant chain (Ii) and HLA-DM molecules on the array of naturally processed peptides displayed by HLA-DR molecules were studied using transfected cell lines. The absence of Ii led to an altered set of HLA-DR-bound peptides as judged by the discriminating responses of alloreactive T cell clones. While most T cell clones raised against DR+Ii+DM+ peripheral blood mononuclear cells (PBMC) failed to respond to DR+Ii-DM- cells, T cell clones raised against DR+Ii-DM- transfectants were not stimulated by DR+Ii+DM+ cells. Furthermore, coexpression of HLA-DM with HLA-DR1 in the absence of Ii augmented responses of anti-PBMC T cell clones but inhibited allorecognition by T cell clones raised against DR+Ii-DM- transfectants. The conformational integrity of the class II molecules, as judged by serology, suggests that the patterns of reactivity of the T cell clones reflect specificity for different alloantigen-bound peptides. Hence, discordant regulation of expression of major histocompatibility complex class II, Ii, and HLA-DM molecules in vivo may lead to the display of novel self-peptides and possible interruption of self-tolerance.

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Citations

Apr 12, 2001·European Journal of Immunology·F A VerreckG J Hämmerling
Feb 22, 2002·Medicinal Research Reviews·Benjamin J McFarland, Craig Beeson
Dec 4, 1998·Springer Seminars in Immunopathology·R Thomas
Mar 31, 2000·Immunologic Research·P E JensenC T Dao
Feb 10, 2009·Immunologic Research·Jason M Weaver, Andrea J Sant
Mar 31, 2000·Trends in Biotechnology·M XuR E Humphreys
Feb 19, 2000·Current Opinion in Immunology·R BuschE D Mellins
Jun 1, 1996·Immunological Reviews·R LechlerL Lightstone
Jan 13, 2000·Immunological Reviews·P E JensenC T Dao
Jun 14, 2000·Journal of Virology·H A PancioL Ratner
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·P RovereJ Davoust
May 10, 2006·The Journal of Experimental Medicine·Christopher A LazarskiAndrea J Sant
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R LechlerG Lombardi
Oct 9, 1998·The Journal of Biological Chemistry·R BuschE D Mellins
Aug 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ioannis KarakikesNelson Fernandez
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P BelmaresElizabeth D Mellins
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chad H Koonce, Elizabeth K Bikoff
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aura MuntasellDolores Jaraquemada
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paula R MengesAndrea J Sant
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard J MellanbyElizabeth K Bikoff

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