In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain

American Journal of Physiology. Endocrinology and Metabolism
Ineke H N LuijtenJan Nedergaard

Abstract

The attractive tenet that recruitment and activation of brown adipose tissue (BAT) and uncoupling protein 1 (UCP1) could counteract the development of obesity and its comorbidities in humans has been experimentally corroborated mainly by experiments demonstrating that UCP1-ablated mice on a C57Bl/6 background (exempt from thermal stress) become more obese when fed a high-fat diet. However, concerns may be raised that this outcome of UCP1 ablation is restricted to this very special inbred and particularly obesity-prone mouse strain. Therefore, we have examined to which degree UCP1 ablation has similar metabolic effects in a mouse strain known to be obesity resistant: the 129S strain. For this, male 129S2/sv or 129SV/Pas mice and corresponding UCP1-knockout mice were fed chow or a high-fat or a cafeteria diet for 4 wk. The absence of UCP1 augmented obesity (weight gain, body fat mass, %body fat, fat depot size) in high-fat diet- and cafeteria-fed mice, with a similar or lower food intake, indicating that, when present, UCP1 indeed decreases metabolic efficiency. The increased obesity was due to a decrease in energy expenditure. The consumption of a high-fat or cafeteria diet increased total BAT UCP1 protein levels in wild-type mi...Continue Reading

References

Sep 6, 1979·Nature·N J Rothwell, M J Stock
Jun 26, 1992·Brain Research·C M Hughes, A Peters
Jun 1, 1992·The American Journal of Physiology·D B WestR L Atkinson
Feb 13, 1984·FEBS Letters·P YoungM Ashwell
May 1, 1994·The American Journal of Physiology·G P EberhartR L Atkinson
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R S SurwitS Collins
Aug 18, 2006·The Journal of Biological Chemistry·Jozef UkropecLeslie P Kozak
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Vladimir KusJan Kopecky
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L P Kozak, R Anunciado-Koza
Jul 25, 2009·The New England Journal of Medicine·James A Timmons, Bente K Pedersen
May 8, 2010·Science·Jeff Ishibashi, Patrick Seale
Jan 22, 2013·The European Journal of Neuroscience·Julie S PendergastShin Yamazaki
Feb 8, 2013·Genes & Development·Jun WuBruce M Spiegelman
Aug 16, 2014·Cell Metabolism·Jan Nedergaard, Barbara Cannon
Jul 2, 2016·Cell·Megan KissigPatrick Seale
Nov 25, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nathan C WinnJaume Padilla
Jul 7, 2017·American Journal of Physiology. Endocrinology and Metabolism·Gabriella von EssenJan Nedergaard
Dec 24, 2018·American Journal of Physiology. Endocrinology and Metabolism·Alexander W FischerJan Nedergaard

❮ Previous
Next ❯

Citations

Nov 30, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Houchun H HuS Sendhil Velan
May 8, 2020·Experimental Physiology·Barbara CannonNatasa Petrovic
Oct 21, 2020·International Journal of Molecular Sciences·Varsha KomallaMehra Haghi
Dec 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Nathalie BouletJan Nedergaard
Dec 10, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Sabri Ahmed RialCatherine Mounier
Mar 1, 2021·Tissue & Cell·Carmen Rodríguez-RiveraCarmen González-Martín
Aug 6, 2021·Scientific Reports·Jaakko L O PohjoismäkiSteve Smith
Aug 20, 2021·Frontiers in Endocrinology·Safaa H HammoudAhmed F El-Yazbi
Aug 18, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tamires Duarte Afonso SerdanSandro Massao Hirabara
Dec 21, 2021·American Journal of Physiology. Endocrinology and Metabolism·Sebastian DieckmannMartin Klingenspor

❮ Previous
Next ❯

Software Mentioned

Multi Gauge

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved