In the centre of an epidemic: Fifteen years of LA-MRSA CC398 at the University Hospital Münster

Veterinary Microbiology
S van AlenKarsten Becker

Abstract

Ten years after initial publications on livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in 2005, we report on the course of the LA-MRSA CC398 epidemic among patients of the University Hospital Münster. This tertiary care facility is located in the Dutch-German border region (EUREGIO), which is characterized by a high density of livestock production and is hence a hotspot for the occurrence of LA-MRSA CC398. Taking advantage of the unique opportunity to track the emergence and spread of MRSA CC398 among humans from the very beginning of the epidemic until today, a total of 6555 non-duplicate MRSA isolates from all screenings and clinical specimens cultivated within the period from 2000 to 2014 were included in the analysis. Retrospectively, the first MRSA CC398 isolate (spa type t034) was obtained from a screening specimen of a patient in 2000, which represents one of the first human-associated LA-MRSA CC398 isolates reported in Europe. After sporadic detections between 2000 and 2004, this clonal lineage accounted for 9.6% of all local MRSA in 2005; a proportion which increased to 35% in 2013 and became stable since then. Considering the period from 2000 to 2014, the group of MRSA CC398 isolates compri...Continue Reading

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Citations

Oct 30, 2016·International Journal of Medical Microbiology : IJMM·Frieder SchaumburgKarsten Becker
Dec 6, 2016·Veterinary Microbiology·Robin KöckStefan Schwarz
Jun 27, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Teresa ConceiçãoMarta Aires-de-Sousa
May 26, 2018·Cellular Microbiology·Keith IretonManmeet Bhalla
Jun 1, 2018·Nature Reviews. Disease Primers·Andie S LeeStephan Harbarth
Nov 9, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Pete KinrossUNKNOWN The European Human LA-Mrsa Study Group
Aug 20, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Rong LuoYanping Luo
Apr 3, 2020·International Journal of Environmental Research and Public Health·Robin KöckAlexander W Friedrich
Apr 6, 2020·MMW Fortschritte der Medizin·Steffen Höring, Sebastian Lemmen
Jan 25, 2018·Annals of Work Exposures and Health·Louise FeldAnne Mette Madsen
May 15, 2020·Clinical Microbiology Reviews·David M P De OliveiraMark J Walker
Feb 2, 2020·Journal of Global Antimicrobial Resistance·Elizabeth A Fisher, Gavin K Paterson

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