PMID: 9426913Aug 1, 1997Paper

In the early stage of major burns, is there a correlation between survival, interleukin-6 levels and oxygen delivery and consumption?

Burns : Journal of the International Society for Burn Injuries
P Y GueugniaudP Petit

Abstract

The correlation between haemodynamic and oxymetric parameters, and circulating cytokines has been little studied for the early phase of extensive burns. The aim of this prospective study was to evaluate survival, looking at variations in cardiac index (CI), oxygen delivery (DO2I) and consumption (VO2I) indexed to the body surface area (BSA), and circulating interleukin-6 (IL6) levels in the acute stage of major burns. Over a 12-month period, all patients admitted within 6 h of extensive thermal injury with total burn surface area (TBSA) of over 60 per cent, necessitating standardized resuscitation and mechanical ventilation, were included. Routine intensive care monitoring, including pulmonary and femoral artery catheters, was set up. During the first 3 days post-injury haemodynamic and oxymetric profiles were recorded every 6 h. Circulating IL6 samples were taken within 6 h of admission, then daily (at 24, 48 and 72 h). A comparison of the results in survivors (S) and non-survivors (NS) at those previously determined times was made. Ten consecutive patients were studied. Six patients survived (Age = 33 +/- 10 years; TBSA = 76 +/- 11 per cent) and four died (Age = 40 +/- 14 years; TBSA = 77 +/- 13 per cent). Similar initial hyp...Continue Reading

References

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Citations

Oct 16, 2001·Burns : Journal of the International Society for Burn Injuries·T RaviKumarM Babu
Apr 20, 1999·Burns : Journal of the International Society for Burn Injuries·F L YehR H Fang
Jan 12, 2000·Burns : Journal of the International Society for Burn Injuries·C HolmW Mühlbauer
Sep 26, 2000·Alcoholism, Clinical and Experimental Research·A ColantoniE J Kovacs
May 29, 1999·AACN Clinical Issues·E de GuzmanK L Mattox
Mar 7, 2013·Burns : Journal of the International Society for Burn Injuries·Heléne NilssonFolke Sjöberg
Mar 26, 2009·Orvosi hetilap·Csaba Csontos
Nov 23, 2011·Burns : Journal of the International Society for Burn Injuries·James E MaceMartin G Schwacha
Aug 19, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael M ChenElizabeth J Kovacs
Nov 24, 2004·Burns : Journal of the International Society for Burn Injuries·C HolmU J Pfeiffer
Apr 1, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Viktor FoldiCsaba Csontos
May 17, 2017·Thorax·B R O'DriscollUNKNOWN BTS Emergency Oxygen Guideline Development Group

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