Abstract
The Oncotype DX recurrence score (RS) assay has been validated for prediction of 10-year risk of distant recurrence and likelihood of benefit from chemotherapy in patients with estrogen receptor (ER)-positive, HER2-negative early breast cancer. Patients with high RS tumors have substantial benefit, and patients with low RS tumors have minimal if any benefit from chemotherapy. Tumor size is used as a key parameter when selecting patients for neoadjuvant chemotherapy. The aim of this study was to assess the distribution of RS in patients selected for neoadjuvant chemotherapy primarily according to tumor size. Patients with ER-positive and HER2-negative tumors that were node-negative or had no more than 1 positive node from three trials were included in this study. Oncotype DX was performed at Genomic Health, Inc., blinded to the clinical data. Descriptive statistics were calculated for distribution of RS for all cases. Of 277 patients, 96 met eligibility criteria, and 81 had sufficient material for analysis. Median tumor size was 40 mm (interquartile range [IQR], 30-50 mm). Grade I, II, and III were observed in 13, 49, and 17 cases, respectively. There was a wide distribution of RS with a median of 21.4 (IQR, 16.05-26.75). In tot...Continue Reading
References
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherN V Dimitrov
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Dec 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G von MinckwitzUNKNOWN German Breast Group
Feb 3, 2005·Journal of the National Cancer Institute·Davide MauriJohn P A Ioannidis
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luca GianniSteven Shak
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manfred KaufmannGunter von Minckwitz
May 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Soonmyung PaikNorman Wolmark
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henri RochéBernard Asselain
Nov 14, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M KaufmannS Loibl
May 19, 2009·Lancet·Paul EllisUNKNOWN TACT Trialists
Dec 17, 2009·The Lancet Oncology·Kathy S AlbainUNKNOWN Breast Cancer Intergroup of North America
May 26, 2010·Journal of Clinical Pathology·Suzanne DruryMitch Dowsett
Aug 10, 2010·The Breast : Official Journal of the European Society of Mastology·A Thiery-VuilleminX Pivot
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederick L BaehnerLaurel A Habel
Feb 4, 2011·The Breast : Official Journal of the European Society of Mastology·Veronique LorgisXavier Pivot
Jul 9, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Xiangnan KongQifeng Yang
Nov 30, 2011·The Breast : Official Journal of the European Society of Mastology·N ChaumardX Pivot
Dec 6, 2011·Journal of the National Cancer Institute·Edith A PerezBeiyun Chen
Dec 14, 2011·Lancet·R PetoK Pritchard
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunter von MinckwitzSibylle Loibl
Feb 15, 2013·Expert Review of Anticancer Therapy·Christos Markopoulos
Mar 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology Clinical Practice
Citations
Nov 7, 2016·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·T P McVeighA J Lowery
Sep 20, 2018·The Breast Journal·Parker C WilsonMalini Harigopal
Jun 5, 2020·Journal of Surgical Oncology·Debbie M JakubowskiFrederick L Baehner
Sep 23, 2018·Breast Cancer Research and Treatment·Hiroji IwataYasuo Ohashi
Nov 25, 2020·Annals of Surgical Oncology·Olga Kantor, Suzanne B Coopey
Nov 6, 2020·Breast Cancer Research and Treatment·Tal SellaAnn H Partridge
Mar 1, 2021·The British Journal of Surgery·M R BolandE W McDermott
Feb 19, 2021·The Breast : Official Journal of the European Society of Mastology·Serafin Morales MurilloAntonieta Salud Salvia