In the eye of the beholder: internally driven uncertainty of danger recruits the amygdala and dorsomedial prefrontal cortex

Journal of Cognitive Neuroscience
Michal ZaretskyTalma Hendler

Abstract

Interpretation of emotional context is a pivotal aspect of understanding social situations. A critical component of this process is assessment of danger levels in the surrounding, which may have a direct effect on the organism's survival. The limbic system has been implicated in mediating this assessment. In situations of uncertainty, the evaluation process may also call for greater involvement of prefrontal cortex for decision-making and planning of an appropriate behavioral response. In the following study, morphed face images depicting emotional expressions were used to examine brain correlates of subjective uncertainty and perceptual ambiguity regarding danger. Fear and neutral expressions of 20 faces were morphed, and each of the face videos was divided into three sequences of equal length representing three levels of objective certainty regarding the expressions neutral, fear, and ambiguous. Sixteen subjects were scanned in a 1.5-T scanner while viewing 60 x 6-sec video sequences and were asked to report their subjective certainty regarding the level of danger surrounding the face on a four-level scale combining definite/maybe and danger/no-danger values. The individual responses were recorded and used as the basis for a ...Continue Reading

References

Jun 1, 1997·Cognitive Psychology·E E Smith, J Jonides
Apr 29, 1998·Brain : a Journal of Neurology·J S MorrisR J Dolan
Jun 12, 1998·Nature·R AdolphsA R Damasio
Aug 14, 1998·Behaviour Research and Therapy·K Mogg, B P Bradley
Aug 26, 1998·Brain Research. Cognitive Brain Research·M D'EspositoJ Lease
Mar 27, 1999·Neuroreport·N KanwisherA Harris
Aug 10, 2000·Experimental Brain Research·R Levy, P S Goldman-Rakic
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·I LiberzonS Minoshima
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
Sep 14, 2001·Psychiatry and Clinical Neurosciences·Y HuangT Someya
Mar 22, 2002·Neuron·Itamar KahnTalma Hendler
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael PetridesStephen Frey
May 17, 2002·Current Opinion in Neurobiology·Ralph Adolphs
Jul 24, 2002·Brain : a Journal of Neurology·Sterling C JohnsonGeorge P Prigatano
Aug 9, 2002·Journal of Cognitive Neuroscience·Bart RypmaMark D'Esposito
Nov 16, 2002·Brain Research. Cognitive Brain Research·Luiz PessoaLeslie G Ungerleider
Dec 14, 2002·Neuroscience and Biobehavioral Reviews·Daniel C Krawczyk
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Feb 1, 2003·Biological Psychiatry·Kezia LangeMary L Phillips
Mar 20, 2003·Biological Psychiatry·Ahmad R HaririDaniel R Weinberger
Jun 20, 2003·NeuroImage·Kirsten G VolzD Yves von Cramon
Mar 6, 2004·Annals of the New York Academy of Sciences·David SkuseKate Lawrence
Mar 30, 2004·CNS Spectrums·K Luan PhanIsrael Liberzon
May 8, 2004·Brain Research. Cognitive Brain Research·Wataru SatoMichikazu Matsumura
May 18, 2004·Brain Research. Brain Research Reviews·Daan BaasRené S Kahn
Oct 16, 2004·Science·K Richard RidderinkhofSander Nieuwenhuis
Oct 21, 2004·Nature Neuroscience·Patrik VuilleumierRaymond J Dolan
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sonia J BishopAndrew D Lawrence
Oct 4, 2005·Journal of Cognitive Neuroscience·Jason P MitchellC Neil Macrae
Oct 12, 2005·Brain Research Bulletin·Kirsten G VolzD Yves von Cramon
Feb 24, 2006·NeuroImage·Steven B MostKent A Kiehl
Mar 31, 2007·Cerebral Cortex·Eran EldarTalma Hendler
Nov 21, 2007·Trends in Cognitive Sciences·Paul J Whalen

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Citations

Sep 2, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shir AtzilRuth Feldman
Aug 14, 2010·Social Cognitive and Affective Neuroscience·Leonhard SchilbachKai Vogeley
Jun 29, 2014·Brain and Cognition·Monica Luciana, Sidney J Segalowitz
May 10, 2015·Consciousness and Cognition·Christophe E de BézenacRhiannon Corcoran
Mar 17, 2015·Frontiers in Human Neuroscience·Hadas Okon-SingerAlexander J Shackman
Oct 16, 2015·Journal of Neuroscience Research·Gary W EvansIsrael Liberzon
Dec 15, 2018·Neuroscience and Biobehavioral Reviews·Jayne MorrissCarien M van Reekum
Jan 6, 2018·Journal of Affective Disorders·Karina QuevedoGarry Smyda

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