In the search for reliable biomarkers for the early diagnosis of autism spectrum disorder: the role of vitamin D

Metabolic Brain Disease
Afaf El-AnsaryLaila Al-Ayadhi

Abstract

Autism spectrum disorder (ASD) affects about 1% of the world's population. Vitamin D is thought to be essential for normal brain development and modulation of the immune system. Worldwide about 1 billion people are affected by vitamin D deficiency. High-sensitivity C-reactive protein (hs-CRP), cytochrome P450 2E1 (CYP2E1) and 8-hydroxy-2'-deoxyguanosine (8-OH-dG) are biomarkers related to inflammation and oxidative stress. In the present study, these biomarkers were together with serum 25-hydroxyvitamin D (25(OH)D3) analyzed in 28 (mean age seven years) Saudi male patients with ASD. The study was conducted to determine if there is any relationship between vitamin D levels, the tested biomarkers and the presence and severity of ASD. The hope was to identify if these biomarkers may be useful for early ASD diagnosis. The Childhood Autism Rating Scale (CARS) and the Social Responsiveness Scale (SRS) were used to measure autism severity. The results of the ASD children were compared with 27 age and gender-matched neurotypical controls. The data indicated that Saudi patients with ASD have significantly lower plasma levels of 25(OH)D3 than neurotypical controls (38 ng/ml compared to 56 ng/ml, respectively; [P = 0.001]). Surprisingly, ...Continue Reading

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Citations

Oct 26, 2018·Journal of Molecular Neuroscience : MN·Geir BjørklundSalvatore Chirumbolo
Mar 26, 2019·The Journal of Endocrinology·Folami Y IderaabdullahCatherine Ann Peterson
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Nov 5, 2021·Journal of Autism and Developmental Disorders·Maria Carmen Gallardo-CarrascoMaría Sánchez-Muñoz

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS
CARS

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