In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters

Psychopharmacology
S M Petralia, Cheryl A Frye

Abstract

There are two types of benzodiazepine receptors, mitochondrial benzodiazepine receptors (MBRs), and gamma-aminobutyric acid (GABA(A))/benzodiazepine receptor complexes (GBRs). MBR activation increases neurosteroidogenesis. Ventral tegmental area (VTA) infusions of the MBR agonist, FGIN 1-27, increase midbrain levels of the progesterone metabolite 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) and lordosis of rats and hamsters. Activation of GBRs leads to membrane hyperpolarization. In the VTA, infusions of GBR agonists enhance 3alpha,5alpha-THP-facilitated lordosis. Thus, if, in the VTA, MBR-mediated increases in 3alpha,5alpha-THP enhance sexual responses via actions at GBRs, then blocking GBRs with picrotoxin will reduce FGIN 1-27-induced increases in sexual behavior of female rodents. Ovariectomized rats and hamsters, with unilateral guide cannula to the VTA, received estradiol benzoate (10 mug; EB) at hour 0. Hamsters also received progesterone (100 mug) at hour 44. At hour 47.5, all animals were infused first with 10 ng or 20 ng picrotoxin or saline, vehicle to the VTA and, 30 min later, with 5 mug/11.4 nM FGIN 1-27 or saline, vehicle. Ten minutes later, animals were tested for sex and motor behavior. Picrotoxin, but n...Continue Reading

References

Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·C A Frye, J F DeBold
Jun 1, 1991·Brain Research Bulletin·C A Lisciotto, J F DeBold
Jan 1, 1986·Annals of the New York Academy of Sciences·P H HutsonG Curzon
Jan 1, 1989·Molecular Neurobiology·M Schumacher, B S McEwen
Jun 1, 1971·The Journal of Endocrinology·L A Ciaccio, R D Lisk
Jul 1, 1980·Brain Research Bulletin·J A MuntzR C Shults
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·G V MiltonC K Erickson
Apr 1, 1994·Neuroscience·T A RoelingR Nieuwenhuys
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·L D Griffin, S H Mellon
Sep 5, 2001·Brain Research·C O JaliffaR E Rosenstein
Oct 16, 2001·International Review of Neurobiology·R C Brown, V Papadopoulos
Dec 18, 2001·Brain Research. Brain Research Reviews·S H MellonN A Compagnone
Dec 18, 2001·Brain Research. Brain Research Reviews·E Plassart-Schiess, E E Baulieu
Mar 3, 2004·Annals of the New York Academy of Sciences·Cheryl A FryeBenjamin Stein
Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C R JefcoateT Yamazaki

❮ Previous
Next ❯

Citations

Aug 1, 2008·Animal : an International Journal of Animal Bioscience·B BeerdaR F Veerkamp
Nov 18, 2006·Behavioural Pharmacology·Maciej KuśmiderMarta Dziedzicka-Wasylewska
Apr 24, 2010·The Journal of Sexual Medicine·Cheryl A Frye, Madeline E Rhodes
Aug 16, 2005·Pharmacology, Biochemistry, and Behavior·E TeodorovM M Bernardi
Jul 17, 2016·The Journal of Endocrinology·Vimal Selvaraj, Lan N Tu
Sep 1, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Radoslaw SlopienAndrea R Genazzani
Aug 4, 2021·Open Biology·Joshua Wang, Kate Beecher
Sep 19, 2006·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.