In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia

International Journal of Radiation Biology
Michele EllenderRoger Cox

Abstract

To assess the sensitivity of ApcMin/+ mice (adenomatous polyposis coli Apc, multiple intestinal neoplasia, Min) to the development of intestinal adenomas after x-irradiation in utero, as neonates, or as young adults. CHB6 ApcMin/+ mice were exposed to an acute dose of 2 Gy x-rays either in utero on day 7 or 14 post-conception, as 2-day or 10-day neonates or as 35-day young adults. Tumour identification and counting was performed 200-214 days later. Irradiation as 10-day-old neonates resulted in a significantly greater overall tumour incidence (average of about 130 tumours per animal) than irradiation as 35-day-old young adults (about 70 tumours). Irradiation as 2-day-old neonates resulted in an intermediate incidence (about 85 tumours). In contrast, the greatest tumour incidence observed after in utero irradiation of ApcMin/+ mice, of about 44 tumours per animal after 2 Gy irradiation at 14 days post-conception, was significantly lower than the incidence in irradiated adults. Tumour incidences after irradiation as 7-day embryos was not significantly raised above numbers in unirradiated controls (about 30 tumours). These tumour numbers include cystic crypts, largely radiation-induced, which were classed as early stage microadeno...Continue Reading

References

Sep 17, 1992·Nature·S M PowellK W Kinzler
Jul 23, 1990·Proceedings. Biological Sciences·D J Winton, B A Ponder
Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·D F Klein, H M Klein
Jan 1, 1986·Canadian Journal of Physiology and Pharmacology·A B Thomson, M Keelan
May 1, 1985·Cell and Tissue Kinetics·W H St Clair, J W Osborne
Dec 22, 1994·The New England Journal of Medicine·A K Rustgi
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Nov 1, 1996·Genes, Chromosomes & Cancer·C Luongo, W F Dove
Feb 1, 1997·The British Journal of Radiology·R Doll, R Wakeford
Apr 18, 1997·Biochimica Et Biophysica Acta·A R ShoemakerW F Dove
Aug 19, 1999·Genes, Chromosomes & Cancer·C W van der Houven van OordtR Fodde
Oct 4, 2000·Physiological Reviews·J Pácha
Mar 20, 2002·Nature Reviews. Cancer·R FoddeH Clevers
Feb 1, 2003·Differentiation; Research in Biological Diversity·Christopher S PottenHideyuki Okano
Aug 29, 2003·Cellular and Molecular Life Sciences : CMLS·P de Santa BarbaraD J Roberts
Oct 9, 2003·Annals of the ICRP·Roger Cox, Christian Streffer
Dec 12, 2003·World Journal of Gastroenterology : WJG·Lei Cheng, Mao-De Lai
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kevin M HaigisWilliam F Dove
Apr 2, 2005·Journal of Radiation Research·Mieko Okamoto, Hiromichi Yonekawa

❮ Previous
Next ❯

Citations

Mar 13, 2008·Journal of the National Cancer Institute·Dale L PrestonRoy E Shore
Jan 12, 2011·International Journal of Radiation Biology·Michele EllenderRoger Cox
Jun 16, 2010·International Journal of Radiation Biology·Jackie HainesSimon Bouffler
Feb 6, 2010·Cancer Science·Toshiaki KokuboYoshiya Shimada
Apr 1, 2013·Journal of Investigative Medicine High Impact Case Reports·Patrick A WilliamsSrinivasan Vijayakumar
Sep 1, 2017·Environmental and Molecular Mutagenesis·Anne GraupnerAnn Karin Olsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.