In utero exposure to cigarette smoke and effects across generations: A conference of animals on asthma

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Barbara HammerSusanne Krauss-Etschmann

Abstract

The prevalence of asthma and chronic obstructive pulmonary disease (COPD) has risen markedly over the last decades and is reaching epidemic proportions. However, underlying molecular mechanisms are not fully understood, hampering the urgently needed development of approaches to prevent these diseases. It is well established from epidemiological studies that prenatal exposure to cigarette smoke is one of the main risk factors for aberrant lung function development or reduced fetal growth, but also for the development of asthma and possibly COPD later in life. Of note, recent evidence suggests that the disease risk can be transferred across generations, that is, from grandparents to their grandchildren. While initial studies in mouse models on in utero smoke exposure have provided important mechanistic insights, there are still knowledge gaps that need to be filled. Thus, in this review, we summarize current knowledge on this topic derived from mouse models, while also introducing two other relevant animal models: the fruit fly Drosophila melanogaster and the zebrafish Danio rerio. This review is based on an intensive review of PubMed-listed transgenerational animal studies from 1902 to 2018 and focuses in detail on selected lite...Continue Reading

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Citations

Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJ A Woodfolk
Oct 21, 2019·Allergologia et immunopathologia·A TeijeiroR M Gomez
Sep 6, 2020·Ecotoxicology and Environmental Safety·Giulianna Echeverria MacedoThaís Posser
Jun 22, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ali AltıntaşVirender K Rehan

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