In utero exposure to diethylstilbestrol and blood DNA methylation in women ages 40-59 years from the sister study

PloS One
Sophia HarlidJack A Taylor

Abstract

In utero exposure to diethylstilbestrol (DES) has been associated with increased risk of adverse health outcomes such as fertility problems and vaginal as well as breast cancer. Animal studies have linked prenatal DES exposure to lasting DNA methylation changes. We investigated genome-wide DNA methylation and in utero DES exposure in a sample of non-Hispanic white women aged 40-59 years from the Sister Study, a large United States cohort study of women with a family history of breast cancer. Using questionnaire information from women and their mothers, we selected 100 women whose mothers reported taking DES while pregnant and 100 control women whose mothers had not taken DES. DNA methylation in blood was measured at 485,577 CpG sites using the Illumina HumanMethylation450 BeadChip. Associations between CpG methylation and DES exposure status were analyzed using robust linear regression with adjustment for blood cell composition and multiple comparisons. Although four CpGs had p<105, after accounting for multiple comparisons using the false discovery rate (FDR), none reached genome-wide significance. In conclusion, adult women exposed to DES in utero had no evidence of large persistent changes in blood DNA methylation.

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Citations

Oct 25, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L E WilsonJ A Taylor
Sep 24, 2015·PloS One·Lauren E WilsonJack A Taylor
Jan 11, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marie-Odile Soyer-GobillardCharles Sultan
Aug 25, 2020·Reviews on Environmental Health·William H GoodsonDavid O Carpenter
Oct 20, 2018·Chemical Communications : Chem Comm·Seung Cheol OhJohannes V Barth
Apr 3, 2019·American Journal of Epidemiology·Lauren E WilsonJack A Taylor
Aug 29, 2021·Environmental Health : a Global Access Science Source·Laura GaspariCharles Sultan

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Methods Mentioned

BETA
chips

Software Mentioned

Illumina GenomeStudio
R package “ methylumi ”

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