In utero exposure to maternal diabetes impairs vascular expression of prostacyclin receptor in rat offspring.

Diabetes
Jean-Paul Duong Van HuyenCéline Fassot

Abstract

To evaluate modifications of arterial structure, gene expression, and function in our model of rats exposed to maternal diabetes. Morphometric analyses of elastic vessels structure and determination of thoracic aortic gene expression profile with oligonucleotide chips (Agilent, G4130, 22k) were performed before the onset of established hypertension (3 months). Arterial parameters of in situ fixed thoracic aorta were not significantly different between control mother offspring and diabetic mother offspring (DMO). The aortic gene expression profile of DMO is characterized by modifications of several members of the arachidonic acid metabolism including a twofold underexpression of prostacyclin receptor, which could contribute to decreased vasodilatation. This was confirmed by ex vivo experiments on isolated aortic rings. Pharmacological studies on conscious rats showed that systolic blood pressure decline in response to a PGI(2) analog was impaired in DMO rats. These results suggest an abnormal vascular fetal programming of prostacyclin receptor in rats exposed in utero to maternal hyperglycemia that is associated with impaired vasodilatation and may be involved in the pathophysiology of hypertension in this model.

References

Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Delphine LamireauSylvain Chemtob
Aug 23, 2003·Biostatistics·M K Kerr, G A Churchill
Jan 30, 2004·The British Journal of Nutrition·Sarah McMullenSimon C Langley-Evans
Aug 31, 2004·The Journal of Nutrition·Guoyao WuThomas E Spencer
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Jul 29, 2005·Journal of the American Society of Nephrology : JASN·V Matti Vehaskari, Lori L Woods
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Kristina M FetalveroKathleen A Martin
Jul 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Lila-Sabrina FetitaJean-François Gautier
May 18, 2007·The New England Journal of Medicine·Julie R Ingelfinger
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Sep 27, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·E J Belin de ChantemèleD Henrion
Sep 30, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Elodie GomezMichel Félétou
Nov 22, 2008·American Journal of Hypertension·Charmaine S WrightEmily Oken
Feb 12, 2009·Seminars in Fetal & Neonatal Medicine·Umberto Simeoni, David J Barker

❮ Previous
Next ❯

Citations

Mar 26, 2013·Nature Reviews. Immunology·Kevan C HeroldJeffrey A Bluestone
Jul 19, 2012·Pediatric Research·Ragheed KatkhudaJeffrey L Segar
Feb 19, 2016·Physiological Reviews·Jude S MortonSandra T Davidge
Dec 26, 2016·Basic Research in Cardiology·Voahanginirina RandriamboavonjyIngrid Fleming

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE16750

Methods Mentioned

BETA
PCR
biopsies

Software Mentioned

GenePix Pro
SAM
SAM ( Significance Analysis of Microarray )

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.