In utero exposure to thiopurines/anti-TNF agents and long-term health outcomes during childhood and adolescence in Denmark

Alimentary Pharmacology & Therapeutics
Bente Mertz NørgårdSonia Friedman

Abstract

Data on long-term health outcomes of children exposed in utero to thiopurines and anti-TNF medications are lacking. To examine the association between in utero exposure to thiopurines and anti-TNF medications and child health outcomes of site-specific groups of infections, a composite endpoint including psychiatric diagnoses/autism spectrum disorder (ASD)/attention deficit hyperactivity disorder (ADHD), and malignancies during childhood/adolescence. A nationwide cohort study based on Danish health registries included 1 311 009 live born children during 1995 through 2015. Outcomes were based on hospital diagnoses (in-patients/out-patients/emergency department contacts). In total, 1048 children were exposed in utero to thiopurines and 1 309 961 were unexposed. The adjusted hazard ratios (HRs) for site-specific groups of infections in the first 3 years of life were close to unity. The adjusted HR of psychiatric diagnoses/ASD/ADHD was 1.11 (95% CI 0.81-1.52). The HR of malignancies was not calculated (only two events among the exposed). In total, 493 children were exposed in utero to anti-TNF medications and 728 055 were unexposed. Within the first year of life, the adjusted HR of respiratory, urological/gynaecological infections a...Continue Reading

References

Jan 1, 1981·The American Journal of the Medical Sciences·S C Nelson, G S Hammer
Aug 1, 1996·Journal of Clinical Epidemiology·J KristensenF B Kristensen
Apr 11, 1997·Schizophrenia Research·J H Gilmore, L F Jarskog
Apr 23, 2002·Teratology·Janine E Polifka, J M Friedman
Mar 19, 2003·Alimentary Pharmacology & Therapeutics·B NørgårdH T Sørensen
Apr 20, 2004·The American Journal of Gastroenterology·David Norman MoskovitzDaniel H Present
Jun 15, 2006·The American Journal of Gastroenterology·Nanne K H de BoerAdriaan A van Bodegraven
Apr 18, 2007·The American Journal of Gastroenterology·Bente NørgårdHenrik T Sørensen
Sep 12, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lee Hilary GoldsteinMatitiahu Berkovitch
Apr 15, 2008·Schizophrenia Bulletin·Urs MeyerBenjamin K Yee
Dec 3, 2010·Journal of Crohn's & Colitis·C Janneke van der WoudeUNKNOWN European Crohn's Colitis Organisation (ECCO)
Apr 2, 2011·Journal of Crohn's & Colitis·Sieglinde AngelbergerClemens Dejaco
May 18, 2011·Journal of Crohn's & Colitis·Lisa ShimMartin D Weltman
Jul 29, 2011·Annals of Neurology·Géraldine FavraisPierre Gressens
Oct 18, 2011·The Journal of Pediatrics·T Michael O'SheaUNKNOWN Extremely Low Gestational Age Newborn (ELGAN) Study Investigators
Dec 4, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Uma MahadevanMaria T Abreu
Dec 25, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J R HutsonG Koren
May 17, 2013·Alimentary Pharmacology & Therapeutics·T G J de MeijUNKNOWN Dutch Initiative on Crohn and Colitis
Jan 21, 2015·Journal of Crohn's & Colitis·C J van der WoudeUNKNOWN European Crohn’s and Colitis Organization
Jun 14, 2015·Digestive Diseases and Sciences·Aoibhlinn O'TooleTracy Tomlinson
Jun 18, 2015·PloS One·Heather A BoydTine Jess
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Apr 3, 2016·Clinical Pharmacology and Therapeutics·Allen Mitchell
Feb 9, 2017·International Journal of Epidemiology·Thierry Boudemaghe, Ihssen Belhadj
Mar 28, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shannon L KanisC Janneke van der Woude
Nov 18, 2018·Journal of Crohn's & Colitis·Laure BenoitPaul Berveiller
Jan 10, 2019·Inflammatory Bowel Diseases·Bente Mertz NørgårdSonia Friedman
Apr 18, 2019·Seminars in Arthritis and Rheumatism·Shweta KishoreVikas Majithia

❮ Previous
Next ❯

Citations

Jul 22, 2021·Journal of Gastroenterology·Akira AndohYoichi Kakuta
Jul 24, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Antoine MeyerRosemary Dray-Spira
Dec 31, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ting-Yun YeLi-Fei Zhu
Sep 1, 2021·Alimentary Pharmacology & Therapeutics·Line Riis JølvingBente Mertz Nørgård

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.