In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II

Journal of Virology
W FengM B McCaw

Abstract

Porcine reproductive and respiratory syndrome (PRRS) consistently elevates the frequency of disease and mortality in young pigs. Many different secondary bacterial diseases occur in PRRS virus (PRRSV)-infected pigs. However, to date, establishing a reproducible experimental model of PRRSV infection in weaned pigs, with subsequent clinical disease following secondary bacterial challenge, has been difficult. PRRSV is frequently isolated during outbreaks from weak-born piglets affected by secondary bacterial diseases. This study was performed to investigate the potential role of intrauterine PRRSV infection on piglet susceptibility to secondary bacterial infection. PRRSV-free pregnant sows were intranasally infected at 98 days of gestation with PRRSV strain SD 23983. All piglets born to the PRRSV-infected sows were viremic. Piglets were removed from the sows at birth and deprived of colostrum. Piglets from PRRSV-infected and noninfected sows were randomly assigned to Streptococcus suis challenge or control subgroups. At 5 days of age, piglets were challenged intranasally with strain MN 87555 of S. suis type II. Total and differential leukocyte counts were performed on blood samples collected at 3 days of age. The numbers of leukoc...Continue Reading

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Citations

Apr 1, 1994·Molecular and Cellular Endocrinology·M T Gillespie, T J Martin
Mar 12, 2003·Veterinary Immunology and Immunopathology·Elida M BautistaWilliam T Golde
Jun 16, 2004·Nature Reviews. Microbiology·Lauren O Bakaletz
Feb 23, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xibao ShiGaiping Zhang
Aug 23, 2005·Infection and Immunity·Francis GirardJohn M Fairbrother
Sep 14, 2010·Virus Research·Raymond R R Rowland
Feb 3, 2016·The Veterinary Record·E CanelliP Martelli
Feb 17, 2009·The Journal of General Virology·Michael S SpilmanTerje Dokland
Oct 31, 2012·Virus Research·Youngnam Kim, Changhee Lee
Sep 9, 2008·Research in Veterinary Science·Zhanzhong ZhaoFeiqun Xue
Aug 19, 2007·Animal Health Research Reviews·Marcelo GottschalkJiangu Xu
May 3, 2011·Emerging Infectious Diseases·Anusak KerdsinKazunori Oishi

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