In utero prednisone exposure affects genital development

The Journal of Urology
Selcuk YucelLaurence S Baskin

Abstract

The etiology of the worldwide incidence of hypospadias remains unexplained. Data from the Center for Disease Control suggest that maternal asthma exposure may be a risk factor. The development of the mouse and human urethra shows significant similarities, such as fusion of 2 epithelial edges, closure of a midline epithelial seam and subsequent cellular remodeling, to justify the use of the mouse as an experimental animal model. Prednisone may act as a weak androgen directly or alternatively lowering testosterone by hypothalamic suppression of gonadotropins. We describe the effects of prednisone on urethral formation in the mouse. The model comprised 10, 20 and 20 timed pregnant C57/6 mice exposed to 1,000, 200 and 100 mg/kg prednisone, respectively, on gestational days 12 through 18. The morphology of the genital tubercles of both sexes were examined on gestational day 19 using histological techniques and 3-dimensional computer reconstruction. Specific attention was focused on the developing urethral seam. Microscopic serial analysis confirmed the presence of an arrest in seam formation in approximately 25% of male fetuses given supraphysiological doses of prednisone (1,000 mg/kg). In contrast, acceleration of urethral fold fus...Continue Reading

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Jun 11, 2003·The Journal of Urology·Selcuk Yucel, Laurence S Baskin

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Citations

Apr 28, 2009·The Journal of Pediatrics·Suzan L CarmichaelUNKNOWN National Birth Defects Prevention Study
Apr 16, 2008·Journal of the American Academy of Dermatology·Joseph LamMagdalene A Dohil
Oct 25, 2008·Journal of Pediatric Urology·Laurence S Baskin
Mar 25, 2014·European Journal of Medical Genetics·Erin M Shih, John M Graham
Mar 7, 2015·Pediatric Surgery International·Mathew GeorgeAndrew J A Holland
Jun 9, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Suzan L CarmichaelEdward J Lammer
Oct 14, 2005·Epidemiology·Henrik Toft SørensenKenneth J Rothman
May 16, 2017·American Journal of Epidemiology·Suzan L CarmichaelUNKNOWN National Birth Defects Prevention Study

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