In utero pyrethroid pesticide exposure in relation to autism spectrum disorder (ASD) and other neurodevelopmental outcomes at 3 years in the MARBLES longitudinal cohort.

Environmental Research
Jacqueline BarkoskiIrva Hertz-Picciotto

Abstract

We assessed the relationships between prenatal pyrethroid pesticide exposure and autism spectrum disorders (ASD) or non-typical development (non-TD) at 3 years. Participants were mother-child pairs (n = 201) in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort. Because familial recurrence risk is high, MARBLES enrolls pregnant women with a family history of ASD. Children from these pregnancies were clinically assessed at 3 years of age and classified into 3 outcome categories: ASD, typically developing (TD), or non-TD (neither TD or ASD). Repeated maternal second and third trimester urine samples were analyzed for pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA). Multinomial logistic regression was used to obtain relative risk ratios (RRR) linking 3-PBA concentrations averaged across each trimester and over pregnancy with child's outcome: ASD or non-TD vs. TD. Models were adjusted for specific gravity, maternal pre-pregnancy BMI, prenatal vitamin use, birth year, home-ownership, and pregnancy concentrations of TCPy (3,5,6-trichloro-2-pyridinol, a metabolite of chlorpyrifos). The median specific gravity corrected 3-PBA concentration of all samples was 1.46 ng/mL. Greater second trimester 3-PBA concent...Continue Reading

References

Sep 1, 1977·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Folstein, M Rutter
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Dec 8, 2004·Environmental Health Perspectives·Russ HauserAntonia M Calafat
Feb 3, 2005·Environmental Health Perspectives·Timothy J ShaferKevin M Crofton
Feb 3, 2006·Environmental Health Perspectives·Chensheng LuRoberto Bravo
Sep 13, 2006·Environmental Health Perspectives·Chensheng LuRoberto Bravo
May 24, 2007·Environmental Health Perspectives·Brenda EskenaziNicholas P Jewell
Aug 31, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Timothy J Shafer, Michael F Hughes
May 26, 2011·Epidemiology·Rebecca J SchmidtIrva Hertz-Picciotto
Jun 29, 2011·Archives of Toxicology·David M Soderlund
Jul 6, 2011·Archives of General Psychiatry·Joachim HallmayerNeil Risch
Apr 12, 2012·Pediatrics·Paula KrakowiakIrva Hertz-Picciotto
Dec 29, 2013·Environmental Monitoring and Assessment·Pamela WoffordMadeline Brattesani
Mar 25, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Sally OzonoffAna-Maria Iosif
May 6, 2014·JAMA : the Journal of the American Medical Association·Sven SandinAbraham Reichenberg
Jun 24, 2014·Environmental Health Perspectives·Janie F SheltonIrva Hertz-Picciotto
Jul 21, 2014·Nature Genetics·Trent GauglerJoseph D Buxbaum
Dec 3, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Katarzyna ChawarskaSusan Bryson
Dec 17, 2014·Toxicology Letters·Mylène RatelleMichèle Bouchard
Mar 3, 2017·Occupational and Environmental Medicine·Jean-François VielCécile Chevrier
May 10, 2017·International Journal of Environmental Research and Public Health·Eric CokerBrenda Eskenazi
May 26, 2017·Environmental Science and Pollution Research International·Chunyan YangYan Hou
May 31, 2017·Environmental Health Perspectives·Robert B GunierBrenda Eskenazi
Aug 16, 2017·Neurotoxicology·Melissa A FurlongStephanie M Engel
Feb 27, 2018·International Journal of Hygiene and Environmental Health·Claire PhilippatIrva Hertz-Picciotto
Jun 4, 2018·Environmental Research·Jacqueline BarkoskiIrva Hertz-Picciotto
Dec 7, 2018·Environmental Health : a Global Access Science Source·Hyeong-Moo ShinIrva Hertz-Picciotto

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