In utero Undernutrition Programs Skeletal and Cardiac Muscle Metabolism

Frontiers in Physiology
B Beauchamp, Mary-Ellen Harper

Abstract

In utero undernutrition is associated with increased risk for insulin resistance, obesity, and cardiovascular disease during adult life. A common phenotype associated with low birth weight is reduced skeletal muscle mass. Given the central role of skeletal muscle in whole body metabolism, alterations in its mass as well as its metabolic characteristics may contribute to disease risk. This review highlights the metabolic alterations in cardiac and skeletal muscle associated with in utero undernutrition and low birth weight. These tissues have high metabolic demands and are known to be sites of major metabolic dysfunction in obesity, type 2 diabetes, and cardiovascular disease. Recent research demonstrates that mitochondrial energetics are decreased in skeletal and cardiac muscles of adult offspring from undernourished mothers. These effects apparently lead to the development of a thrifty phenotype, which may represent overall a compensatory mechanism programmed in utero to handle times of limited nutrient availability. However, in an environment characterized by food abundance, the effects are maladaptive and increase adulthood risks of metabolic disease.

References

Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Nov 1, 1990·The Journal of Clinical Investigation·F ZurloE Ravussin
Sep 9, 1989·Lancet·D J BarkerS J Simmonds
Apr 10, 1993·Lancet·D J BarkerJ S Robinson
Oct 14, 1998·Journal of Molecular and Cellular Cardiology·V G SharovH N Sabbah
Oct 28, 1999·The American Journal of Clinical Nutrition·A C RavelliO P Bleker
Dec 13, 2000·Journal of Molecular and Cellular Cardiology·V G SharovH N Sabbah
Dec 12, 2001·Circulation·P RazeghiH Taegtmeyer
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Marie-Claude BattistaMichèle Brochu
Feb 28, 2003·Reviews of Physiology, Biochemistry and Pharmacology·M Flück, H Hoppeler
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·T S HermannC Torp-Pedersen
Mar 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Mary A SelakRebecca A Simmons
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Serge LuquetPaul A Grimaldi
Nov 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Iyalla E PetersideRebecca A Simmons
May 6, 2004·Annals of the New York Academy of Sciences·Hyeong Kyu ParkHong Kyu Lee
Jul 9, 2004·Pediatric Research·Peter D Gluckman, Mark A Hanson
May 17, 2005·Reproductive Toxicology·Rebecca C PainterOtto P Bleker
Jun 11, 2005·The British Journal of Nutrition·Kuljeet K CheemaParamjit S Tappia
Jun 21, 2005·Annals of the New York Academy of Sciences·Hong Kyu LeeYoungmi Kim Pak
Jul 1, 2005·Physiological Reviews·William C StanleyGary D Lopaschuk
Jun 10, 2006·The Journal of Physiology·Mei J ZhuMin Du
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Christine B JensenAllan A Vaag
Jul 20, 2007·The Proceedings of the Nutrition Society·Jonathan C K WellsMary S Fewtrell
Mar 11, 2008·The Journal of Biological Chemistry·Nupur RaychaudhuriSherin U Devaskar
May 17, 2008·Seminars in Perinatology·Mert Ozan Bahtiyar, Joshua A Copel
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg

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Citations

Nov 2, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Semone B Myrie, Mark A Pinder
Jan 26, 2017·Frontiers in Physiology·Isaac Peña-VillalobosPablo Sabat
Jun 8, 2018·Frontiers in Physiology·Pilar Rodríguez-RodríguezSilvia M Arribas

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Methods Mentioned

BETA
histone acetylation

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