In vitro α-amylase inhibitory effect of TLC isolates of Aloe megalacantha baker and Aloe monticola Reynolds

BMC Complementary and Alternative Medicine
Gebretsadkan HintsaHayelom Gebrekirstos Mengesha

Abstract

About 425 million adults had diabetes mellitus globally in 2017. Type 2 diabetes accounts for the enormous majority of diabetes cases and it is gradually growing which is predicted to increase by 48% in 2045. Imbalanced cellular carbohydrate and lipid metabolism cause an increase in postprandial blood glucose level which eventually leads to the onset and progression of type 2 diabetes mellitus. The lack of effective and safe carbohydrate hydrolyzing enzyme inhibitors contributes to the increasing prevalence. Thus, this study was targeted to assess the α-amylase inhibitory potential of isolates obtained from Aloe megalacantha Baker and Aloe monticola Reynolds, which are among the commonly used folkloric remedies for the management of diabetes mellitus. The α-amylase inhibitory effect of Aloe megalacantha Baker and Aloe monticola Reynolds were evaluated using the 3,5-dinitro salicylic acid method. 2, 2-Diphenyl-2-picrylhydrazyl free radical scavenging property was also used to test the antioxidant effect of both plants. Results were analysed using GraphPad Prism software version 8. The more polar isolates (AM1 and AG1) were possessed stronger α-amylase inhibition activity than the leaves latex and the other strains (AM2 and AG2)....Continue Reading

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Citations

May 23, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Leake GebremeskelTewolde Teklu
Oct 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Gedefaw Getnet AmareYaschilal Muche Belayneh
Mar 25, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Tsgabu Yohannes ArayaGetu Kahsay
Jun 27, 2021·Chemical Biology & Drug Design·Navjot KaurSanjeev Kumar Sahu

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Software Mentioned

GraphPad Prism
GraphPad

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