PMID: 3272347Jan 1, 1988Paper

In vitro acetylation of the liver HMG non-histone proteins and its modulation by spermine and dexamethasone during aging of rats

Molecular Biology Reports
S Prasad, M K Thakur


The in vitro acetylation of HMG proteins was studied using liver slices of young (18-week) and old (138-week) male rats. Acetylation of total HMG proteins is lower in old age. The incorporation of (14C) acetate into individual HMG proteins varies remarkably with advancing age. Whereas acetylation of high mol. wt. proteins (HMG 1 and 2) is higher, that of low mol. wt. proteins (HMG 14 and 17) is lower in the liver of young rats as compared to the old ones. Spermine stimulates the acetylation of HMG 1 and 14 in young and HMG 1, 2 and 14 in old age. It inhibits the acetylation of HMG 17 in both ages. Dexamethasone decreases the level of incorporation of (14C) into HMG 1 and 17 in young and HMG 14 and 17 in old rats. On the other hand, it stimulates the acetylation of HMG 14 by two-fold in young and that of HMG 1 and 2 by more than three-fold in old rats. Such alteration in the acetylation of HMG proteins may account for age-related changes in the structure and function of chromatin.


Apr 6, 1978·Biochimica Et Biophysica Acta·J JänneA Raina
Feb 24, 1989·Science·M E BianchiG Paonessa
Jan 1, 1985·Molecular and Cellular Endocrinology·E Cooper, S W Spaulding
Aug 15, 1988·Biochemical and Biophysical Research Communications·E A Alexandrova, B G Beltchev
Aug 10, 1987·FEBS Letters·Q A VuD A Nelson
Jan 1, 1986·CRC Critical Reviews in Biochemistry·R S WuW M Bonner
Apr 8, 1986·Biochemistry·D Sen, D M Crothers
Oct 31, 1984·Mechanisms of Ageing and Development·M K Thakur
May 10, 1980·Nucleic Acids Research·R Reeves, E P Candido
Jul 1, 1983·Archives of Gerontology and Geriatrics·M K Thakur
Aug 6, 1982·Molecular and Cellular Biochemistry·H J SaxholmH C Pitot
Jan 1, 1982·European Journal of Biochemistry·B DodJ Parello
Nov 1, 1980·European Journal of Biochemistry·J BöhmR Knippers

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