PMID: 6110722Nov 1, 1980Paper

In vitro actions of NN-dimethyl-2-aminoindane and related compounds

The Journal of Pharmacy and Pharmacology
H J Little, J M Rees

Abstract

The actions of 2-aminoindane, 2-amino-1,2,3,4-tetrahydronaphthalene and amphetamine and their N-methyl and NN-dimethyl derivatives on the guinea-pig ileum were compared. All, except the tertiary 2-aminoindane, inhibited the responses to electrical stimulation and it is suggested that this is not fully explained by their sympathomimetic properties. NN-Diemthyl-2-aminoindane increased these responses and caused contractions of the unstimulated ileum due to a nicotine-like action. The indane series was more effective in producing contractions of the ileum than the other compounds. The three tertiary derivatives antagonized competitively the actions of histamine on the ileum and those of 5-hydroxy-tryptamine on the rat uterus.

References

Mar 1, 1969·British Journal of Pharmacology·I R Innes, J D Kohli
Jun 1, 1954·British Journal of Pharmacology and Chemotherapy·J H GADDUM, K A HAMEED
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·I R INNES
Jan 1, 1955·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J H GADDUMF F STEPHENS

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