In vitro actions of ranitidine, a new histamine H2-receptor antagonist

Agents and Actions
M J Daly, R Stables

Abstract

Ranitidine has been tested on isolated guinea-pig right atrium and rat uterine horn, tissues known to possess histamine H2-receptors; and on isolated guinea-pig ileum a tissue containing histamine H1-receptors. These experiments have shown ranitidine to be a potent competitive antagonist of histamine at H2-receptor sites in vitro. This action is selective since high concentrations of ranitidine do not affect beta-adrenoceptor, histamine H1-receptor and muscarinic receptor mediated responses.

References

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Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

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Citations

Nov 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·G Bertaccini, G Coruzzi
Jan 1, 1981·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H G DammannB Simon
Jan 1, 1984·Pharmacology & Therapeutics·R E Pounder
Jan 7, 1982·The New England Journal of Medicine·M DanilewitzB Hirschowitz
May 1, 1981·Digestive Diseases and Sciences·K M WalusE D Jacobson
May 1, 1981·The British Journal of Dermatology·M G Davies, M W Greaves
Jul 1, 1982·Agents and Actions·T J Rising, S Lewis
Apr 1, 1982·Agents and Actions·G Bertaccini, G Coruzzi
Nov 1, 1980·Agents and Actions·I R SmithK M Metters
Jan 1, 1989·Drug Metabolism and Drug Interactions·G Saccomani, S J Hersey

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