In Vitro Activation: A Possible New Frontier for Treatment of Primary Ovarian Insufficiency

Reproductive Sciences
Christina N CordeiroJames H Segars

Abstract

In vitro activation (IVA) represents a new frontier in the treatment of women with primary ovarian insufficiency as well as patients with cancer desiring fertility preservation. Here, we review the biological basis of IVA and the recent translation of IVA to humans by targeting Hippo and Akt-signaling pathways. We then provide a new integrated viewpoint on IVA, highlighting basic science research on the aspects of follicular development and ovarian tissue transplantation which may potentially optimize future translational research on IVA. Specific topics discussed include cryopreservation techniques, additional IVA pathway targets, the roles of actin polymerization, paracrine and endocrine factors, and the role of mechanical signaling and associated tissue rigidity in controlling ovarian follicular activation. Further research and improved understanding is needed to optimize success of IVA.

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Citations

Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tuo ZhangChao Wang
Oct 6, 2016·The Journal of Clinical Endocrinology and Metabolism·Ophelia YinJames H Segars
Apr 4, 2017·Journal of Assisted Reproduction and Genetics·Camille LadanyiJames H Segars
Apr 25, 2018·Journal of Assisted Reproduction and Genetics·Jaimin S ShahJames H Segars
Feb 11, 2020·Frontiers in Medicine·Mudan YeLi Li
Aug 23, 2017·Expert Review of Hematology·Mahmoud SalamaPeter Mallmann
Nov 7, 2018·Fertility and Sterility·Stine Aagaard LundingAnette Tønnes Pedersen
May 1, 2021·International Journal of Molecular Sciences·Kim Cat Tuyen Vo, Kazuhiro Kawamura
May 27, 2021·Stem Cells and Development·Julie A MacDonaldJonathan L Tilly

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Methods Mentioned

BETA
mechanical dissociation
biopsy
nucleotide exchange

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