PMID: 701665Nov 1, 1978Paper

In vitro activation of the alternative pathway of complement by settled grain dust

The Journal of Allergy and Clinical Immunology
S A OlenchockG Taylor

Abstract

Settled grain dust was collected from several active grain elevators in the Superior-Duluth areas of the United States. Particle size distribution (47% less than 5 micrometer) and endotoxin contamination (429 ng/gm) of the dust were similar to those reported for the airborne parent dust. Human complement uas activated in vitro in a dose-response manner which could be quantified. This hemolytic consumption was via the alternative pathway as defined by ethylenediaminetertraacetic acid/ethylene-glycol-bis-(beta-amino-ethyl ether) N,N'-tetraacetic acid (EDTA/EGTA) differential serum chelation, factor B conversion, and complement reductions in serum from guinea pigs deficient in C4. It is proposed that continuous low-dose exposure to aerosolized, biologically active rafter dust could contribute to the respiratory insult of grain workers.

References

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Citations

Jun 1, 1982·Environmental Research·J O HillB R Scott
Apr 9, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H S Park, K S Jung
Jan 1, 1984·Journal of Toxicology and Environmental Health·S A OlenchockP L Lu
Jan 1, 1984·Journal of Toxicology and Environmental Health·G H WirtzS A Olenchock
Apr 1, 1986·Environmental Health Perspectives·W V DashekC A Young
Apr 1, 1986·Environmental Health Perspectives·N StepnerR Baumal
Apr 1, 1986·Environmental Health Perspectives·J A CooperJ B Gee
Apr 1, 1986·Environmental Health Perspectives·T A ThomsonP J Nicholls
Jan 1, 1989·Critical Reviews in Toxicology·D B Warheit
Jan 1, 1988·Experimental Lung Research·D B WarheitA R Brody
Aug 1, 1988·Environmental Research·D L SkeaI Broder
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H ParkY Kim
Jan 1, 1986·American Journal of Industrial Medicine·J Dutkiewicz
Apr 1, 1984·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·G H Wirtz, S A Olenchock
Jan 1, 1982·Drug Intelligence & Clinical Pharmacy·C S Tse, P K Raghuprasad

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