PMID: 22358361Feb 24, 2012Paper

In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Liliane Alves ScheidSydney Hartz Alves

Abstract

In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility accompanying the development of resistance to fluconazole. Our findings confirmed the ability of C. dubliniensis isolates to become resistant to fluconazole and indicated that this resistance was crossed with ketoconazole, itraconazole, ravuconazole and terbinafine. We also tested combinations of terbinafine, amphotericin B, itraconazole and voriconazole against both groups of isolates in a checkerboard assay. Surprisingly, most combinations evidenced indifferent interactions, and the best synergism appeared when terbinafine and itraconazole were combined against the fluconazole-resistant group.

References

Feb 26, 2004·Antimicrobial Agents and Chemotherapy·Melissa D JohnsonJohn H Rex
May 4, 2004·International Journal of Antimicrobial Agents·C Gil-Lamaignere, F-M C Müller

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Citations

Apr 23, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Ravikumar Bapurao ShindeSankunny Mohan Karuppayil
Oct 5, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Thaís Felli KubiçaSydney Hartz Alves
Oct 25, 2016·Medical Mycology·Rodrigo Almeida-PaesRosely Maria Zancopé-Oliveira
Feb 9, 2017·Frontiers in Microbiology·Liliana ScorzoniAna M Fusco-Almeida

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