PMID: 9420028Jan 7, 1998Paper

In vitro activities of beta-lactam-beta-lactamase inhibitor combinations against Stenotrophomonas maltophilia: correlation between methods for testing inhibitory activity, time-kill curves, and bactericidal activity

Antimicrobial Agents and Chemotherapy
J L Muñoz BellidoJ A García-Rodríguez

Abstract

The activities of ampicillin, ampicillin-sulbactam, amoxicillin, amoxicillin-clavulanic acid, ticarcillin, ticarcillin-clavulanic acid, piperacillin, piperacillin-tazobactam, aztreonam, and aztreonam-clavulanic against Stenotrophomonas maltophilia strains for which the MICs of penicillins and commercially available beta-lactam-beta-lactamase inhibitor combinations were higher than the breakpoints usually recommended for Pseudomonas aeruginosa in commercially available broth microdilution methods were tested by the agar diffusion, agar dilution, and broth microdilution methods. Time-kill curve studies were performed when discrepancies between these methods were observed. The MICs obtained by the commercially available broth microdilution method, the agar dilution method, and the broth microdilution method were almost identical. Twenty-five percent of the strains tested showed inhibition diameters of > or =15 mm for ticarcillin-clavulanic acid, and 43.7% of the strains tested showed inhibition diameters of > or =18 mm for piperacillin-tazobactam by the agar diffusion method. The time-kill curves for these strains confirmed the results obtained by dilution methods. Aztreonam-clavulanic acid (2:1) at concentrations of < or =16 micr...Continue Reading

References

Apr 1, 1991·The Journal of Antimicrobial Chemotherapy·J A García-RodríguezE García Sánchez
May 1, 1991·Diagnostic Microbiology and Infectious Disease·J A García-RodríguezJ L Muñoz Bellido
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·K BushA A Medeiros
Sep 1, 1994·Antimicrobial Agents and Chemotherapy·R PatonS G Amyes
Oct 1, 1995·Antimicrobial Agents and Chemotherapy·C D PoulosA McGeer

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Citations

Apr 17, 2001·Antimicrobial Agents and Chemotherapy·S ValdezateR Cantón
Mar 6, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A C Nicodemo, J I Garcia Paez
Feb 7, 2018·Indian Journal of Medical Microbiology·Lipika SinghalVikas Gautam
Jan 31, 2002·The Annals of Pharmacotherapy·Nathan P DownhourDavid E Nix

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