PMID: 9174186Jun 1, 1997Paper

In vitro activities of ciprofloxacin and rifampin alone and in combination against growing and nongrowing strains of methicillin-susceptible and methicillin-resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy
D BahlM H Miller

Abstract

We characterized the effects of ciprofloxacin and rifampin alone and in combination on Staphylococcus aureus in vitro. The effects of drug combinations (e.g., indifferent, antagonistic, or additive interactions) on growth inhibition were compared by disk approximation studies and by determining the fractional inhibitory concentrations. Bactericidal effects in log-phase bacteria and in nongrowing isolates were characterized by time-kill methods. The effect of drug combinations was dependent upon whether or not cells were growing and whether killing or growth inhibition was the endpoint used to measure drug interaction. Despite bactericidal antagonism in time-kill experiments, our in vitro studies suggest several possible explanations for the observed benefits in patients treated with a combination of ciprofloxacin and rifampin for deep-seated staphylococcal infections. Notably, when growth inhibition rather than killing was used to characterize drug interaction, indifference rather than antagonism was observed. An additive bactericidal effect was observed in nongrowing bacteria suspended in phosphate-buffered saline. While rifampin antagonized the bactericidal effects of ciprofloxacin, ciprofloxacin did not antagonize the bacter...Continue Reading

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Citations

Sep 22, 2010·Antimicrobial Agents and Chemotherapy·Rafael San JuanJose Maria Aguado
Jan 8, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G L Drusano
Feb 16, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Otto S KluinHenny C van der Mei
Apr 12, 2012·Clinical Microbiology Reviews·Sebastian J van HalIain B Gosbell
Feb 17, 2019·Journal of Biomedical Materials Research. Part a·Rebecca M HaleyHorst A von Recum
Dec 14, 1999·International Journal of Antimicrobial Agents·E Gutschik
Jun 24, 2016·Journal of Medicinal Chemistry·Zhenkun Ma, Anthony Simon Lynch

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