In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum

The Journal of Antimicrobial Chemotherapy
X YouJ R Mead

Abstract

Using a chemiluminescence immunoassay, paromomycin and lasalocid were shown to inhibit Cryptosporidium parvum growth in Madin-Darby canine kidney cells in a concentration-dependent manner. The median effective concentrations (EC50s) for paromomycin and lasalocid were 1184 mg/L and 0.4 mg/L, respectively. Neither drug was cytotoxic to host cells at concentrations up to five times their EC50s. Drug combination studies were conducted and the resulting data were analysed by the median-effect principle and combination index method. Statistically significant synergy was observed when combinations of paromomycin and lasalocid were used at ratios of 5000:1 and 2500:1. A possible mechanism for synergy is discussed.

Citations

May 11, 2011·Parasitology Research·Liang WuJian-ping Cao
Jun 20, 2001·Journal of Microbiological Methods·P LawtonA F Pétavy
Jun 17, 2000·Veterinary Parasitology·J A Castro HermidaM E Ares-Mazás
Jul 20, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jan R Mead
Jul 5, 2002·Clinical Microbiology Reviews·Michael J Arrowood
Jun 11, 2002·The Journal of Parasitology·T SréterI Varga

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