Abstract
The in vitro activity of tigecycline was compared with those of benzylpenicillin, piperacillin + tazobactam, cefoxitin, imipenem, metronidazole, clindamycin, and tetracycline against 249 Gram-negative anaerobic bacteria (158 Bacteroides fragilis group, 27 non-fragilis Bacteroides spp., 44 Prevotella spp., and 20 miscellaneous), recently isolated from 8 general hospitals in Athens, Greece. Overall tigecycline MIC(50) and MIC(90) were 0.25 and 2 mg/L, respectively, whereas B. fragilis group MIC(50) and MIC(90) were 0.5 and 4 mg/L, respectively. In total, 93% of the isolates were susceptible to tigecycline (MIC </= 4 mg/L) and no high-level resistance (MIC >/= 32 mg/L) was detected. In addition, tigecycline exhibited good activity against metronidazole- and tetracycline-resistant isolates (MIC(90), 0.5 and 8 mg/L, respectively). In summary, tigecycline exhibits good in vitro activity against Gram-negative anaerobic bacteria isolated in Greece, as well as stability to the most common occurring resistance mechanisms, attributes that make this parenteral agent an attractive alternative for use against infections involving these microorganisms.
References
Dec 1, 1998·International Journal of Antimicrobial Agents·F MoryL Dubreuil
Mar 18, 1999·FEMS Microbiology Letters·M M LubbeL J Chalkley
Dec 10, 1999·The Journal of Antimicrobial Chemotherapy·J S BrazierB I Duerden
May 8, 2000·The Journal of Antimicrobial Chemotherapy·J OteoJ L Gómez-Garcés
Sep 19, 2000·Antimicrobial Agents and Chemotherapy·E J GoldsteinK Tyrrell
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Edlund, C E Nord
Mar 21, 2001·Antimicrobial Agents and Chemotherapy·K E AldridgeJ E Rosenblatt
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Carmen BetriuUNKNOWN Spanish Group of Tigecycline
Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V.O. RotimiF.B. Khodakhast
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D R SnydmanS L Gorbach
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Lee-Jene TengKwen-Tay Luh
Jul 10, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M HedbergUNKNOWN ESCMID Study Group on Antimicrobial Resistance in Anaerobic Bacteria
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinUNKNOWN Infectious Diseases Society of America
Feb 26, 2004·Antimicrobial Agents and Chemotherapy·N V JacobusD R Snydman
May 7, 2004·The Journal of Antimicrobial Chemotherapy·Laura M KoethLuc J Dubreuil
Jun 11, 2004·The Journal of Antimicrobial Chemotherapy·Micaela Gal, J S Brazier
Sep 15, 2004·Journal of Clinical Microbiology·Jeffrey M SchapiroAjit P Limaye
Dec 8, 2004·Diagnostic Microbiology and Infectious Disease·Ying-yuan ZhangFu Wang
Apr 13, 2005·The Journal of Antimicrobial Chemotherapy·David R SnydmanLaura A McDermott
Jun 14, 2005·The Journal of Antimicrobial Chemotherapy·C BetriuJ J Picazo
Aug 18, 2005·Diagnostic Microbiology and Infectious Disease·Helio S SaderThomas R Fritsche
Aug 18, 2005·Diagnostic Microbiology and Infectious Disease·Thomas R FritscheRonald N Jones
Citations
Nov 22, 2012·The Journal of Antibiotics·Junlin HeLiying Yu
Aug 9, 2012·Surgical Infections·Jaime Ruiz-TovarMiguel Gras
Apr 4, 2008·The Journal of Antimicrobial Chemotherapy·Joseph PapaparaskevasAthina Avlamis
May 14, 2008·Antimicrobial Agents and Chemotherapy·Carmen BetriuJuan J Picazo
Dec 8, 2010·Future Microbiology·Corentine AlauzetAlain Lozniewski
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·S MeenakshiS Inbasekaran
Dec 23, 2008·International Journal of Antimicrobial Agents·L AlouL Aguilar
Aug 7, 2007·Expert Review of Anti-infective Therapy·Lyudmila BoyanovaIvan Mitov
Jul 25, 2015·Annals of Laboratory Medicine·Yangsoon LeeKyungwon Lee
Dec 15, 2007·Journal of Chemotherapy·J M CasellasUNKNOWN Argentinean Collaborative Test Group
Aug 31, 2013·Journal of Natural Products·Jianjun ZhangJon S Thorson