In vitro activity and beta-lactamase stability of N-formimidoyl thienamycin compared to that of second and third generation cephalosporins

Chemotherapy
A Vuye

Abstract

N-Formimidoyl thienamycin (MK0787) was found to be active against 21 gram-negative isolates, selected for their beta-lactamase production. None of the crude beta-lactamases could hydrolyze MK0787 or cefoxitin, in contrast to cefotaxime which was moderately attacked by a number of enzymes. MK0787 behaved as a moderate inhibitor of most beta-lactamases, whereas cefoxitin and cefotaxime were strong inhibitors of cephalosporinases but not of broad-spectrum enzymes. The new compound had good penetration characteristics in a strain of Enterobacter cloacae, in contrast to cefoxitin. Against a number of trained cefamandole- and cefoxitin-resistant variants, MK0787 was clearly the most active of the compounds tested.

Citations

Oct 1, 1984·European Journal of Clinical Microbiology·M Barza
Jan 1, 1985·Pharmacology & Therapeutics·R B SykesE A Swabb
Mar 1, 1985·Diagnostic Microbiology and Infectious Disease·A L BarryR Kundargi
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Sep 1, 1993·Journal of Clinical Microbiology·G L CooperP Michelsen

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