In vitro activity of A-16686, a new glycopeptide

Chemotherapy
H C Neu, N M Neu

Abstract

A-16686 is a novel glycopeptide antibiotic derived from Actinoplanes. A-16686 inhibited hemolytic streptococci groups A, B, C, F, and G at concentrations of less than or equal to 0.06 to 0.5 microgram/ml, with 90% inhibited by 0.5 microgram/ml, including erythromycin-resistant isolates. S. bovis, various viridans groups streptococci, S. mitis, S. mutans, and S. sanguis were inhibited by less than or equal to 1 microgram/ml, and MICs of S. faecalis and S. faecium were 0.5-2 micrograms/ml. Most staphylococci, including methicillin-resistant strains, were inhibited by 1 or 2 micrograms/ml. A-16686 was bactericidal with minimal difference between MIC and MBC for gram-positive species. A-16686 did not inhibit Enterobacteriaceae or Pseudomonas.

Citations

Dec 20, 2002·Biopolymers·Dewey G McCaffertyWenkai Li
Dec 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S DixsonJ M Hamilton-Miller
May 1, 1989·Diagnostic Microbiology and Infectious Disease·R N Jones, A L Barry
Oct 1, 1993·Diagnostic Microbiology and Infectious Disease·R ScottiB P Goldstein
Jul 4, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·M ItohT Iga
Oct 1, 1995·The American Journal of Medicine·K V RolstonG P Bodey
Jan 10, 2012·Bioorganic & Medicinal Chemistry·Amanda J HoertzDewey G McCafferty
Jul 28, 2010·FEMS Microbiology Letters·John W SchmidtDewey G McCafferty
Mar 24, 2005·The Annals of Pharmacotherapy·Debra K FarverSteven C Lee

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