PMID: 11328780May 1, 2001Paper

In vitro activity of antimicrobial agents against the endosymbiont Wolbachia pipientis

The Journal of Antimicrobial Chemotherapy
P G HermansAlexander J Trees

Abstract

Arthropod-transmitted (filarial) nematodes are important causes of disease in humans in tropical countries, yet no safe drug appropriate for mass delivery kills the adult worms. However, most filarial nematodes contain rickettsia-like bacteria of the genus Wolbachia, and related bacteria also occur in insects. There is increasing evidence that these bacteria have significant functions in the biology of filarial nematodes. They are thus important targets in the search for antifilarial drugs and experiments in animals and humans have suggested that antibiotic therapy has potential in treating filarial infections. To optimize future clinical trials there is a need for a fast and simple in vitro drug screen to compare drug efficacies against Wolbachia. In the absence of Wolbachia-infected nematode cell lines, we have utilized an Aedes albopictus insect cell line, naturally infected with Wolbachia, to test the activity of antimicrobial agents. Of the five antibiotics tested, doxycycline, oxytetracycline and rifampicin showed good activity (MICs of 0.0625, 4 and 0.0625 mg/L, respectively) whereas ciprofloxacin and penicillin were shown to have no effect.

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Citations

Feb 21, 2002·Current Infectious Disease Reports·Paul B. Keiser, Thomas B. Nutman
Oct 4, 2011·Indian Journal of Clinical Biochemistry : IJCB·Rachna Sabharwal MahajanMaryada Venkatarami Reddy
Sep 24, 2002·Experimental Parasitology·Ramakrishna U RaoGary J Weil
Feb 24, 2006·Antimicrobial Agents and Chemotherapy·Benjamin L MakepeaceAlexander J Trees
Feb 2, 2002·Applied and Environmental Microbiology·Stephen L DobsonScott L O'Neill
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Kelly L JohnstonMark J Taylor
Mar 23, 2013·International Journal of Medical Microbiology : IJMM·Jennifer VollmerKenneth Pfarr
Jul 9, 2002·The Journal of Parasitology·R Rao, Gary J Well
Mar 4, 2020·Antimicrobial Agents and Chemotherapy·Jose E Pietri, Dangsheng Liang
Apr 20, 2002·Current Opinion in Infectious Diseases·M J Taylor, A Hoerauf
May 10, 2019·Science Translational Medicine·Malina A BakowskiCase W McNamara
Jul 22, 2019·Tropical Medicine and Infectious Disease·Malina A Bakowski, Case W McNamara
Nov 13, 2020·Microbiology and Molecular Biology Reviews : MMBR·Florent Masson, Bruno Lemaitre
Oct 14, 2021·Parasitology Research·Adela NgwewondoSabine Specht

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