In vitro activity of apalcillin compared with that of other new penicillins and anti-Pseudomonas cephalosporins.

Antimicrobial Agents and Chemotherapy
H C Neu, P Labthavikul

Abstract

Apalcillin, a naphthydridine derivative of ampicillin, was compared with ticarcillin, azlocillin, mezlocillin, piperacillin, cefotaxime, and cefoperazone against gram-negative and gram-positive bacterial isolates and with cefsulodin and tobramycin against Pseudomonas aeruginosa. The minimal concentrations of apalcillin at which 50 and 90% of hospital isolates of Escherichia coli were inhibited were similar to those of mezlocillin and piperacillin (1.6 and 100 micrograms/ml, respectively). Apalcillin had minimal inhibitory concentrations similar to those of piperacillin against Citrobacter freundii and Citrobacter diversus. Against Klebsiella, apalcillin inhibited 50% of organisms at a concentration of 6.3 micrograms/ml, similar to piperacillin. The activity of apalcillin against Enterobacter (E. aerogenes, E. cloacae, and E. agglomerans) was similar to that of mezlocillin and piperacillin and greater than that of ticarcillin. The activity of apalcillin against Proteus mirabilis was similar to that of the other agents, as was its activity against indole-positive Proteus and Providencia. Only 40% of Serratia were inhibited at an apalcillin concentration of 25 micrograms/ml. Apalcillin was as active as piperacillin but twofold les...Continue Reading

References

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May 1, 1978·Antimicrobial Agents and Chemotherapy·H C Neu, K P Fu

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Citations

Jan 1, 1985·Diagnostic Microbiology and Infectious Disease·A L BarryC Thornsberry
Jan 1, 1992·Diagnostic Microbiology and Infectious Disease·J A García-RodríguezM I García García
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Sep 1, 1983·Infection·O BrücknerM Trautmann

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