PMID: 9546418Apr 18, 1998Paper

In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs

The American Journal of Tropical Medicine and Hygiene
Bruno PradinesJ C Doury

Abstract

The in vitro activity of artemether against 56 African isolates of Plasmodium falciparum from Senegal was evaluated using an isotope-based drug susceptibility semi-microtest. The 50% inhibitory concentration (IC50) values for artemether were in a narrow range from 0.8 to 15.2 nM (mean IC50 = 3.43 nM) and the 95% confidence interval (CI) was 2.50-4.36 nM. Artemether was equally effective on chloroquine-sensitive and chloroquine-resistant isolates (mean IC50 = 346 nM, 95% CI = 2.08-4.84 nM versus mean IC50 = 2.80 nM, 95% CI = 2.00-3.60 nM). There was a significant positive correlation between responses to artemether and mefloquine (r2 = 0.36, P < 0.001), artemether and quinine (r2 = 0.085, P < 0.05), artemether and halofantrine (r2 = 0.075, P < 0.05), quinine and mefloquine (r2 = 0.205, P < 0.01), quinine and halofantrine (r2 = 0.124, P < 0.05), and mefloquine and halofantrine (r2 = 0.801, P < 0.001). A positive correlation between these drugs suggests in vitro cross-resistance or at least in vitro cross-susceptibility.

Citations

Mar 9, 2005·Emerging Infectious Diseases·Christophe RogierOdile Mercereau-Puijalon
Dec 13, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Halidou TintoUmberto D'Alessandro
Mar 22, 2013·PloS One·Machteld E BoelFrançois H Nosten
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Marie L AncelinHenri J Vial
Jan 22, 2003·Tropical Medicine & International Health : TM & IH·Jérôme Mezui Me NdongPhilippe Deloron
Oct 3, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·D C Warhurst, M T Duraisingh
Feb 14, 2018·The American Journal of Tropical Medicine and Hygiene·Karamoko NiaréOgobara K Doumbo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

The American Journal of Tropical Medicine and Hygiene
Bruno PradinesM Kombila
Tropical Medicine and Parasitology : Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft Für Technische Zusammenarbeit (GTZ)
J C DouryJ Le Bras
© 2022 Meta ULC. All rights reserved