In-vitro activity of avermectins against Mycobacterium ulcerans

PLoS Neglected Tropical Diseases
Till F OmansenTimothy Stinear

Abstract

Mycobacterium ulcerans causes Buruli ulcer (BU), a debilitating infection of subcutaneous tissue. There is a WHO-recommended antibiotic treatment requiring an 8-week course of streptomycin and rifampicin. This regime has revolutionized the treatment of BU but there are problems that include reliance on daily streptomycin injections and side effects such as ototoxicity. Trials of all-oral treatments for BU show promise but additional drug combinations that make BU treatment safer and shorter would be welcome. Following on from reports that avermectins have activity against Mycobacterium tuberculosis, we tested the in-vitro efficacy of ivermectin and moxidectin on M. ulcerans. We observed minimum inhibitory concentrations of 4-8 μg/ml and time-kill assays using wild type and bioluminescent M. ulcerans showed a significant dose-dependent reduction in M. ulcerans viability over 8-weeks. A synergistic killing-effect with rifampicin was also observed. Avermectins are well tolerated, widely available and inexpensive. Based on our in vitro findings we suggest that avermectins should be further evaluated for the treatment of BU.

References

Jan 1, 1996·European Journal of Clinical Pharmacology·O Z BarakaJ F Williams
Sep 29, 1999·Lancet·T S van der WerfK Asiedu
Oct 23, 2002·The American Journal of Tropical Medicine and Hygiene·Ymkje StienstraTjip S van der Werf
Dec 20, 2005·Tropical Medicine & International Health : TM & IH·Ymkje StienstraTjip S van der Werf
Apr 25, 2006·The Lancet Infectious Diseases·Vinciane SizaireFrançoise Portaels
Jun 4, 2010·PloS One·Nuria AndreuSiouxsie Wiles
Aug 5, 2010·The American Journal of Tropical Medicine and Hygiene·Ghislain Emmanuel SopohFrançoise Portaels
Nov 4, 2011·Human Vaccines·Thorbjorg Einarsdottir, Kris Huygen
Dec 14, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Willemien A NienhuisTjip S van der Werf
Nov 21, 2012·Antimicrobial Agents and Chemotherapy·Leah E LimCharles J Thompson
Apr 17, 2013·The Journal of Antimicrobial Chemotherapy·Sirwan Muhammed Ameen, Michel Drancourt
Jul 23, 2013·PLoS Neglected Tropical Diseases·N Deborah FriedmanDaniel P O'Brien
Dec 25, 2013·PLoS Neglected Tropical Diseases·Tianyu ZhangEric L Nuermberger

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Citations

Aug 14, 2015·PLoS Neglected Tropical Diseases·Nicole ScherrSantiago Ramón-García
Dec 3, 2015·PLoS Neglected Tropical Diseases·Daniel P O'BrienEugene Athan
Mar 14, 2017·Trends in Parasitology·Roz LaingEileen Devaney
Dec 15, 2017·Clinical Microbiology Reviews·Dezemon ZingueMichel Drancourt
Feb 23, 2018·Antimicrobial Resistance and Infection Control·Shoaib AshrafXin Zhao
Oct 10, 2019·The American Journal of Tropical Medicine and Hygiene·Till F OmansenTimothy P Stinear
Feb 13, 2019·Frontiers in Microbiology·Andrea Miró-CanturriYounes Smani
Jun 7, 2017·Internal Medicine Journal·Daniel P O'BrienEugene Athan
Feb 12, 2020·Antibiotics·Olga PaciosMaria Tomás
Nov 16, 2020·Trends in Parasitology·Richard J MartinShivani Choudhary
Oct 20, 2017·Current Opinion in Biotechnology·Qiang GaoLixin Zhang
Nov 30, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·A L Tatu, T Nadasdy

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Software Mentioned

Mars
GraphPad Prism
Omega

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