PMID: 8599191Oct 1, 1995Paper

In vitro activity of BaH1, the main hemorrhagic toxin of Bothrops asper snake venom on bovine endothelial cells

Toxicon : Official Journal of the International Society on Toxinology
G BorkowM Ovadia

Abstract

Incubation of BaH1, the main hemorrhagic toxin purified from the venom of Bothrops asper, with endothelial cells caused the appearance of spaces among the cells. This effect became more noticeable with increasing hemorrhagin concentration and longer incubation time. Later, the cells became rounded and detached from the substrate into the medium. Augmentation of Trypan blue did not stain the detached cells, indicating their viability. Moreover, after washing the floating cells from the toxin they could be recultivated: they again spread on the substrate and proliferated, demonstrating that BaHl is not directly cytotoxic to the endothelial cells.

References

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Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·C L OwnbyH Sugihara
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·J G SotoS A Minton
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·M Ovadia
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·C L Ownby, C R Geren
Oct 25, 1973·Biochimica Et Biophysica Acta·A OsakaE Habermann
Dec 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·G BorkowM Ovadia
Jan 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezM Ovadia
Aug 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·L MoreiraJ M Gutiérrez
Apr 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·B LomonteL A Hanson
Sep 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·G BorkowM Ovadia

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Citations

Dec 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·G BorkowM Ovadia
Nov 14, 2003·Toxicology and Applied Pharmacology·Teresa EscalanteJosé María Gutiérrez
Aug 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·S G Anderson, C L Ownby
Jul 10, 1999·Toxicon : Official Journal of the International Society on Toxinology·A RucavadoJ M Gutiérrez
May 19, 2005·Biological Chemistry·Mirta SchattnerAna Marisa Chudzinski-Tavassi
Mar 24, 2009·Toxicon : Official Journal of the International Society on Toxinology·José María GutiérrezTeresa Escalante
Oct 19, 2006·Toxicon : Official Journal of the International Society on Toxinology·Guilherme FranciscoAriovaldo P Cruz-Neto
Sep 5, 2006·Toxicon : Official Journal of the International Society on Toxinology·Caroline Krieger de Moraes, Heloisa Sobreiro Selistre-de-Araujo
Dec 13, 2005·Microvascular Research·José María GutiérrezAlexandra Rucavado
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·José María GutiérrezCecilia Díaz
Dec 3, 2011·Toxicon : Official Journal of the International Society on Toxinology·Soledad BustilloLaura C Leiva
Mar 5, 1999·Critical Reviews in Toxicology·R HatiK K Bhattacharyya
Dec 30, 2008·Toxicon : Official Journal of the International Society on Toxinology·Yamileth Angulo, Bruno Lomonte

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