In vitro activity of cefpirome compared with other third generation cephalosporins against nosocomial isolates in Argentina

Infection
J M CasellasS Arduino

Abstract

The in vitro activity of cefpirome was evaluated against strains that showed conflicting results for third generation cephalosporins. Against isolates with derepressed inducible chromosomal cephalosporinase (n = 40) cefpirome was the sole cephalosporin with an MIC90 in the susceptible range; Klebsiella spp. with plasmid-mediated beta-lactamases (broad spectrum SHV-2 or SHV-2 type) (n = 40) remained most susceptible to ceftizoxime and cefpirome; against aminoglycoside-resistant Pseudomonas aeruginosa (n = 50), cefpirome was as active as ceftazidime and cefoperazone; against oxacillin-susceptible and oxacillin-resistant Staphylococcus spp., (n = 40), cefpirome was more active than other third generation cephalosporins but killing was inadequate against both oxacillin-resistant staphylococci and enterococci.

References

Nov 1, 1986·Antimicrobial Agents and Chemotherapy·S KobayashiK Fujimoto
Apr 1, 1985·The Journal of Antimicrobial Chemotherapy·R WiseL J Piddock
Jun 1, 1984·Antimicrobial Agents and Chemotherapy·R N JonesA L Barry

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