In Vitro Activity of Ceftazidime-Avibactam against Clinical Isolates of Enterobacteriaceae and Pseudomonas aeruginosa Collected in Asia-Pacific Countries: Results from the INFORM Global Surveillance Program, 2012 to 2015

Antimicrobial Agents and Chemotherapy
James A KarlowskyDaniel F Sahm

Abstract

The in vitro activities of ceftazidime-avibactam and comparators against 9,149 isolates of Enterobacteriaceae and 2,038 isolates of Pseudomonas aeruginosa collected by 42 medical centers in nine countries in the Asia-Pacific region from 2012 to 2015 were determined as part of the International Network for Optimal Resistance Monitoring (INFORM) global surveillance program. Antimicrobial susceptibility testing was conducted by Clinical and Laboratory Standards Institute (CLSI) broth microdilution, and isolate subset analysis was performed on the basis of the resistant phenotypes and β-lactamase content. Ceftazidime-avibactam demonstrated potent in vitro activity (MIC, ≤8 μg/ml) against all Enterobacteriaceae tested (99.0% susceptible) and was the most active against isolates that were metallo-β-lactamase (MBL) negative (99.8% susceptible). Against P. aeruginosa, 92.6% of all isolates and 96.1% of MBL-negative isolates were susceptible to ceftazidime-avibactam (MIC, ≤8 μg/ml). The rates of susceptibility to ceftazidime-avibactam ranged from 97.0% (Philippines) to 100% (Hong Kong, South Korea) for Enterobacteriaceae and from 83.1% (Thailand) to 100% (Hong Kong) among P. aeruginosa isolates, with lower susceptibilities being observe...Continue Reading

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Citations

Feb 23, 2019·Journal of the Pediatric Infectious Diseases Society·Pranita D Tamma, Alice J Hsu
Aug 1, 2019·The Journal of Antimicrobial Chemotherapy·Stephan GöttigThomas A Wichelhaus
Aug 15, 2018·Antimicrobial Agents and Chemotherapy·Adam StewartDavid Paterson
Jul 12, 2019·Journal of Global Antimicrobial Resistance·Elmano Ramalheira, Gregory G Stone
Oct 4, 2020·Current Opinion in Infectious Diseases·Abigail K KoisJoseph L Kuti
May 26, 2021·Antimicrobial Agents and Chemotherapy·Erin K McCrearyPranita D Tamma
Sep 11, 2021·Folia Microbiologica·Natália Kehl Moreira, Juliana Caierão
Jul 30, 2021·Acta Microbiologica Et Immunologica Hungarica·Hasan Selcuk OzgerEsin Senol

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