Abstract
Recent clinical isolates of key Gram-negative and Gram-positive bacteria were collected in 2012 from hospitalised patients in medical centres in four European countries (France, Germany, Italy and Spain) and were tested using standard broth microdilution methodology to assess the impact of 4 mg/L avibactam on the in vitro activities of ceftazidime, ceftaroline and aztreonam. Against Enterobacteriaceae, addition of avibactam significantly enhanced the level of activity of these antimicrobials. MIC(90) values (minimum inhibitory concentration that inhibits 90% of the isolates) of ceftazidime, ceftaroline and aztreonam for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Morganella morganii were reduced up to 128-fold or greater when combined with avibactam. A two-fold reduction in the MIC(90) of ceftazidime to 8 mg/L was noted in Pseudomonas aeruginosa isolates when combined with avibactam, whereas little effect of avibactam was noted on the MIC values of the test compounds when tested against Acinetobacter baumannii isolates. Avibactam had little effect on the excellent activity of ceftazidime, ceftaroline and aztreonam against Haemophilus influenzae. It had no impac...Continue Reading
References
Aug 12, 2008·The Journal of Antimicrobial Chemotherapy·David M LivermoreNeil Woodford
Jun 17, 2009·Antimicrobial Agents and Chemotherapy·Andrea EndimianiRobert A Bonomo
Nov 3, 2010·Antimicrobial Agents and Chemotherapy·David M LivermoreNeil Woodford
Mar 2, 2011·Antimicrobial Agents and Chemotherapy·P R S Lagacé-WiensG G Zhanel
Mar 23, 2011·Antimicrobial Agents and Chemotherapy·A WalktyG G Zhanel
Aug 16, 2011·Current Opinion in Microbiology·Ken Coleman
Nov 2, 2011·International Journal of Antimicrobial Agents·Z AktaşO Oncul
Jan 5, 2012·Antimicrobial Agents and Chemotherapy·Premavathy LevasseurChristine Miossec
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·David E EhmannStewart L Fisher
Aug 28, 2013·Antimicrobial Agents and Chemotherapy·James A KarlowskyGeorge G Zhanel
Nov 20, 2013·Antimicrobial Agents and Chemotherapy·Mariana CastanheiraHelio S Sader
Dec 18, 2013·Antimicrobial Agents and Chemotherapy·Xiaojuan WangHui Wang
Jan 1, 2014·Antimicrobial Agents and Chemotherapy·Helio S SaderRonald N Jones
Citations
Nov 27, 2015·Expert Opinion on Pharmacotherapy·Shang-Yi LinPo-Ren Hsueh
Jul 21, 2016·Journal of Global Antimicrobial Resistance·Ramalingam SekarMurugesan Amudhan
Mar 8, 2016·Clinical Therapeutics·Roopali SharmaStanley Moy
Oct 27, 2015·International Journal of Antimicrobial Agents·Karen Bush
Oct 22, 2015·Hemodialysis International·Jessica Hui Fen GohClaude J Renaud
Aug 12, 2015·Annals of Intensive Care·Étienne RuppéFrançois Barbier
Jul 13, 2016·Expert Review of Anti-infective Therapy·Matthew E FalagasKonstantinos Z Vardakas
Mar 10, 2017·Infectious Diseases·Sofia MarakiMatthew E Falagas
Nov 8, 2017·Infection·Felipe Francisco TuonMarcelo R Formigoni-Pinto
Jul 19, 2018·Antibiotics·Daniela de Araújo Viana MarquesAna Lúcia Figueiredo Porto
Oct 21, 2015·Antimicrobial Agents and Chemotherapy·Hervé DupontHedi Mammeri
Jun 21, 2017·Antimicrobial Agents and Chemotherapy·James A KarlowskyPatricia A Bradford
May 25, 2016·Antimicrobial Agents and Chemotherapy·Wright W NicholsDaniel F Sahm
Nov 14, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Menglan ZhouYingchun Xu
Jan 11, 2019·Expert Opinion on Drug Metabolism & Toxicology·Ilias KaraiskosHelen Giamarellou
Dec 12, 2018·Antimicrobial Agents and Chemotherapy·Claire Amaris HobsonAndré Birgy
Jan 9, 2019·Antimicrobial Agents and Chemotherapy·Dandan YinUNKNOWN China Antimicrobial Surveillance Network (CHINET) Study Group
Oct 3, 2019·Current Opinion in Infectious Diseases·Antonio VenaMatteo Bassetti
Mar 4, 2020·Antimicrobial Agents and Chemotherapy·Snehal PalweArun S Kharat
Jun 4, 2020·Journal of Clinical Pharmacology·Jun WangYang Wang
Feb 6, 2017·Journal of Pharmacokinetics and Pharmacodynamics·Karen Bush, Malcolm G P Page
Apr 20, 2018·Drugs·Matt Shirley
Aug 22, 2020·Infection and Drug Resistance·Dan LiWei Zhang
Sep 3, 2020·Infection·Stamatis KarakonstantisAchilleas Gikas
Jul 29, 2020·The Journal of Microbiology·Shivakumar S Jalde, Hyun Kyung Choi
Nov 18, 2020·International Journal of Molecular Sciences·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Nov 13, 2020·Clinical Microbiology Reviews·Dafna YahavLeonard Leibovici
Apr 4, 2021·Microorganisms·Elena XuDespoina Koulenti
Oct 13, 2021·Current Opinion in Infectious Diseases·Matteo BassettiDaniele Roberto Giacobbe