In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates

International Journal of Antimicrobial Agents
Raymond TestaPatrice Nordmann

Abstract

Recent clinical isolates of key Gram-negative and Gram-positive bacteria were collected in 2012 from hospitalised patients in medical centres in four European countries (France, Germany, Italy and Spain) and were tested using standard broth microdilution methodology to assess the impact of 4 mg/L avibactam on the in vitro activities of ceftazidime, ceftaroline and aztreonam. Against Enterobacteriaceae, addition of avibactam significantly enhanced the level of activity of these antimicrobials. MIC(90) values (minimum inhibitory concentration that inhibits 90% of the isolates) of ceftazidime, ceftaroline and aztreonam for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Morganella morganii were reduced up to 128-fold or greater when combined with avibactam. A two-fold reduction in the MIC(90) of ceftazidime to 8 mg/L was noted in Pseudomonas aeruginosa isolates when combined with avibactam, whereas little effect of avibactam was noted on the MIC values of the test compounds when tested against Acinetobacter baumannii isolates. Avibactam had little effect on the excellent activity of ceftazidime, ceftaroline and aztreonam against Haemophilus influenzae. It had no impac...Continue Reading

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Citations

Nov 27, 2015·Expert Opinion on Pharmacotherapy·Shang-Yi LinPo-Ren Hsueh
Jul 21, 2016·Journal of Global Antimicrobial Resistance·Ramalingam SekarMurugesan Amudhan
Aug 12, 2015·Annals of Intensive Care·Étienne RuppéFrançois Barbier
Jul 13, 2016·Expert Review of Anti-infective Therapy·Matthew E FalagasKonstantinos Z Vardakas
Nov 8, 2017·Infection·Felipe Francisco TuonMarcelo R Formigoni-Pinto
Jul 19, 2018·Antibiotics·Daniela de Araújo Viana MarquesAna Lúcia Figueiredo Porto
Nov 14, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Menglan ZhouYingchun Xu
Jan 11, 2019·Expert Opinion on Drug Metabolism & Toxicology·Ilias KaraiskosHelen Giamarellou
Oct 3, 2019·Current Opinion in Infectious Diseases·Antonio VenaMatteo Bassetti
Feb 6, 2017·Journal of Pharmacokinetics and Pharmacodynamics·Karen Bush, Malcolm G P Page
Jul 29, 2020·The Journal of Microbiology·Shivakumar S Jalde, Hyun Kyung Choi
Nov 18, 2020·International Journal of Molecular Sciences·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Nov 13, 2020·Clinical Microbiology Reviews·Dafna YahavLeonard Leibovici
Oct 13, 2021·Current Opinion in Infectious Diseases·Matteo BassettiDaniele Roberto Giacobbe

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