In vitro activity of ceftazidime/avibactam against isolates of Pseudomonas aeruginosa collected in European countries: INFORM global surveillance 2012-15

The Journal of Antimicrobial Chemotherapy
Krystyna KazmierczakDaniel F Sahm

Abstract

The activity of ceftazidime/avibactam was assessed against 5716 Pseudomonas aeruginosa isolates collected from 96 medical centres in 18 European countries as part of the International Network for Optimal Resistance Monitoring (INFORM) global surveillance programme from 2012 to 2015. Activity was analysed against subsets of isolates based on resistance phenotypes and β-lactamase content. Antimicrobial susceptibility testing was performed by broth microdilution and β-lactamase genes were detected by PCR screening and sequencing. Ceftazidime/avibactam was highly active in vitro against the overall collection of P. aeruginosa isolates and colistin-resistant isolates (92.4% and 92.9% susceptible, respectively). Although activity was slightly reduced against MBL-negative subsets of ceftazidime-non-susceptible (79.6% susceptible), meropenem-non-susceptible (85.1% susceptible) and MDR (81.6% susceptible) P. aeruginosa, ceftazidime/avibactam remained the second most active entity, after colistin, compared with all other comparator agents tested. At the country level, susceptibility to ceftazidime/avibactam ranged from 74.6% to 99.6%, with decreased susceptibilities only observed in countries where MBLs are more frequently encountered, s...Continue Reading

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Citations

Dec 19, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Snehal PalweArun S Kharat
Sep 21, 2019·Emerging Infectious Diseases·Yan-Yan HuRong Zhang
Apr 23, 2019·Expert Review of Anti-infective Therapy·Georgios L VoulgarisMatthew E Falagas
Feb 9, 2020·Antibiotics·Ilias Karaiskos, Helen Giamarellou
Jun 28, 2019·Frontiers in Public Health·Ilias KaraiskosGaryphallia Poulakou
Oct 6, 2019·The Journal of Antimicrobial Chemotherapy·Stamatis KarakonstantisAchilleas Gikas
Nov 13, 2020·Clinical Microbiology Reviews·Dafna YahavLeonard Leibovici
Jan 7, 2022·International Journal of Antimicrobial Agents·Laura CorbellaJosé M Aguado

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