In vitro activity of ceftolozane/tazobactam against clinical isolates of Pseudomonas aeruginosa and Enterobacteriaceae recovered in Spanish medical centres: Results of the CENIT study

International Journal of Antimicrobial Agents
Marta TatoCENIT Study Group

Abstract

Ceftolozane/tazobactam is a novel antimicrobial agent with activity against Pseudomonas aeruginosa, including drug-resistant strains, and other Gram-negative pathogens, including most extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. The CENIT study evaluated the in vitro activity of ceftolozane/tazobactam and comparators against clinical isolates of P. aeruginosa (n=500) and Enterobacteriaceae (n=500) collected from patients with complicated intra-abdominal, complicated urinary tract, lower respiratory tract or bloodstream infections in 10 medical centres in Spain (January-September 2013). Antimicrobial susceptibility was determined by the ISO broth microdilution method using commercial dry-form panels and results were interpreted per EUCAST and CLSI guidelines and for ceftolozane/tazobactam with FDA criteria. Ceftolozane/tazobactam and ceftolozane alone were the most potent (MIC50/90, 0.5/4mg/L) agents tested against all P. aeruginosa isolates. This advantage was maintained regardless of resistance phenotype, even against isolates resistant to multiple antibiotics. Ceftolozane/tazobactam demonstrated excellent overall activity (MIC50/90, 0.25/0.5mg/L) against all 250 Escherichia coli isolates, including isola...Continue Reading

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Citations

Apr 22, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David van Duin, Robert A Bonomo
Dec 14, 2016·Antimicrobial Agents and Chemotherapy·Juan José CastónJulián Torre-Cisneros
Apr 12, 2019·Drugs·Shio-Shin JeanUNKNOWN International Society of Antimicrobial Chemotherapy (ISAC)
Aug 25, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Manuel Díaz-CañestroAntonio Oliver
Jan 12, 2021·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Alessandro Russo
Nov 13, 2020·Clinical Microbiology Reviews·Dafna YahavLeonard Leibovici
May 25, 2021·Frontiers in Medicine·Silvia CorcioneFrancesco Giuseppe De Rosa
Sep 29, 2021·Current Opinion in Infectious Diseases·Matteo BassettiAntonio Vena

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