In Vitro Activity of Clofazimine against Nontuberculous Mycobacteria Isolated in Beijing, China

Antimicrobial Agents and Chemotherapy
Jingjing LuoHairong Huang

Abstract

Due to the natural resistance of nontuberculous mycobacteria (NTM) to many antibiotics, the treatment of diseases caused by NTM is often long-term but unsuccessful. The main goal of this study was to evaluate the in vitro susceptibilities to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing, China. Furthermore, 47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium (SGM) species. The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well. Clofazimine exhibited excellent activity against both reference strains and clinical isolates of different SGM species, and most of the strains had MICs far below 1 μg/ml. Although the majority of the clinical isolates of Mycobacterium abscessus and Mycobacterium fortuitum had MICs higher than 2 μg/ml, 17 out of the 30 reference strains of different RGM species had MICs below 1 μg/ml in vitro According to the MIC distributions, the tentative epidemiological cutoff (ECOFF) values for Mycobacterium kansasii, Mycobacterium avium, and Mycobacterium intracellulare were defined at 0.5 μg/ml, 1 μg/ml, and 2 μg/ml, respectively. Intriguingly, sing...Continue Reading

References

Jun 7, 1996·Journal of Chromatography. B, Biomedical Applications·R O'ConnorR O'Kennedy
Dec 17, 2009·International Journal of Antimicrobial Agents·Jakko van IngenDick van Soolingen
Feb 9, 2010·International Journal of Antimicrobial Agents·Gwan-Han ShenJiann-Hwa Chen
May 6, 2010·American Journal of Respiratory and Critical Care Medicine·Armand Van DeunHans L Rieder
Oct 3, 2012·Antimicrobial Agents and Chemotherapy·Jakko van IngenCharles L Daley
Mar 6, 2013·Seminars in Respiratory and Critical Care Medicine·Joseph O Falkinham
Apr 20, 2013·The European Respiratory Journal·Wouter HoefslootUNKNOWN Nontuberculous Mycobacteria Network European Trials Group
Mar 5, 2014·Antimicrobial Agents and Chemotherapy·Ruben C HartkoornStewart T Cole
Apr 17, 2014·The Journal of Biological Chemistry·Abhijith RadhakrishnanEdward W Yu
Jan 27, 2015·American Journal of Respiratory and Critical Care Medicine·Andreas H DiaconCarl M Mendel
Jun 6, 2015·The Journal of Antimicrobial Chemotherapy·Shuo ZhangYing Zhang
Jan 3, 2016·The Journal of Infection·S CowmanM R Loebinger
Mar 1, 2017·Antimicrobial Agents and Chemotherapy·Yu PangYanlin Zhao
Mar 23, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F AlcaideM Santin
Mar 30, 2017·Antimicrobial Agents and Chemotherapy·Bumhee YangWon-Jung Koh

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Citations

Dec 5, 2018·Antimicrobial Agents and Chemotherapy·Barbara A Brown-Elliott, Richard J Wallace
Mar 13, 2019·International Journal of Mycobacteriology·Beverley Cherie Millar, John Edmund Moore
Jun 2, 2020·Future Microbiology·Niccolò RiccardiAntonio Di Biagio
Mar 24, 2020·Expert Opinion on Pharmacotherapy·Maria-Carmen Muñoz-EgeaJaime Esteban
Jun 18, 2020·Open Forum Infectious Diseases·Ethan ValinetzRupali Jain
Feb 24, 2021·Antimicrobial Agents and Chemotherapy·Bettina SchulthessPeter Sander
May 11, 2021·Frontiers in Medicine·Mohammad Javad NasiriMehdi Mirsaeidi
Jun 22, 2021·Journal of Global Antimicrobial Resistance·Bahareh HajikhaniMehid Mirsaeidi
Jul 23, 2021·Pulmonary Pharmacology & Therapeutics·Herman O I PfaeffleScott K Heysell
Jul 12, 2021·Chest·Nakwon KwakJae-Joon Yim
May 31, 2019·Current Opinion in Organ Transplantation·Shweta Anjan, Michele I Morris

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