In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi

Memórias do Instituto Oswaldo Cruz
Patricia B PetrayEder L Romero

Abstract

We investigated the in vitro action of an hydrosoluble 2-nitroimidazole, Etanidazole (EZL), against Trypanosoma cruzi, the etiologic agent of Chagas disease. EZL displayed lethal activity against isolated trypomastigotes as well as amastigotes of T. cruzi (RA strain) growing in Vero cells or J774 macrophages, without affecting host cell viability. Although not completely equivalent to Benznidazole (BZL), the reference drug for Chagas chemotherapy, EZL takes advantage in exerting its anti-T. cruzi activity for longer periods without serious toxic side effects, as those recorded in BZL-treated patients. Our present results encourage further experiments to study in depth the trypanocidal properties of this drug already licensed for use in human cancers.

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Citations

Apr 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maria Jose MorillaEder Lilia Romero
Jun 23, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Miguel A ChenaCarlos Wong
Nov 28, 2009·Advanced Drug Delivery Reviews·Eder Lilia Romero, Maria Jose Morilla
Jul 2, 2008·European Journal of Medicinal Chemistry·Dorota OlenderLucjusz Zaprutko
May 11, 2013·Bioorganic & Medicinal Chemistry Letters·Bessy GutiérrezJorge González
Dec 23, 2009·Memórias do Instituto Oswaldo Cruz·Cristina HerreraSilvia Sepúlveda-Boza
Feb 15, 2020·Current Drug Delivery·Esmeralda Sánchez-PavónAngel Ramos-Ligonio
Jun 24, 2008·Journal of Medicinal Chemistry·Jean Jerley Nogueira SilvaDouglas Wagner Franco

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