PMID: 11328781May 1, 2001Paper

In vitro activity of garlic oil and four diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae

The Journal of Antimicrobial Chemotherapy
S Tsao, M Yin

Abstract

The in vitro antibacterial activities of garlic oil and four diallyl sulphides naturally occurring in this oil were studied against Pseudomonas aeruginosa and Klebsiella pneumoniae (total 237 clinical isolates). Garlic oil at 4 x MIC could reduce original inoculum to <or=2 log(10) in both P. aeruginosa and K. pneumoniae within 8 h. The MIC values of four diallyl sulphides against these two pathogens followed the order diallyl monosulphide > diallyl disulphide > diallyl trisulphide (DAT) > diallyl tetrasulphide (DATS) (P < 0.05). Most interactions of ceftazidime, gentamicin, imipenem and meropenem with DAT or DATS, determined according to the fractional inhibitory concentration index, showed synergic or additive effects. These results suggest that garlic oil, DAT and DATS may have potential for the prevention or treatment of nosocomial, antibiotic-resistant bacterial infections.

References

Jul 30, 1993·Biochemical and Biophysical Research Communications·S ShojiM Kino
Nov 1, 1996·Applied and Environmental Microbiology·R NaganawaA Suzuki
Jun 3, 1998·Current Microbiology·S E HsiehJ G Chung
Oct 20, 1998·The Journal of Hospital Infection·C H LuH W Chang
May 5, 1999·Bioscience, Biotechnology, and Biochemistry·H YoshidaA Suzuki
Jul 27, 1999·FEMS Microbiology Letters·T H FarmerD J Payne
Mar 23, 2000·Chemico-biological Interactions·D A DelkerD W Rosenberg
May 2, 2000·Applied and Environmental Microbiology·E A O'GaraD J Maslin
Apr 1, 1991·Planta·H Zygmunt, H Krystyna

❮ Previous
Next ❯

Citations

May 28, 2005·Archives of Pharmacal Research·Soon-Kyoung Kwon, Aree Moon
Jan 10, 2012·Journal of the American Chemical Society·Júlio S RebouçasBrian R James
Apr 13, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Nilufer Yalindag-OzturkPelin Cengiz
May 3, 2007·Journal of Medicinal Food·Noori S Al-WailiKarem Al-Sahlani
Oct 22, 2010·Canadian Journal of Microbiology·Snowber YousufLuqman Ahmad Khan
Mar 16, 2011·International Journal of General Medicine·Mostafa Yakoot, Amel Salem
Apr 7, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Angela FilocamoArjan Narbad
Feb 8, 2011·Experimental Gerontology·Anna A PowolnyAlfred L Fisher
Mar 3, 2009·Environmental and Molecular Mutagenesis·Małgorzata IciekLidia Włodek
Mar 8, 2006·The Journal of Nutritional Biochemistry·Angelo De MartinoGiuseppe Rotilio
Oct 27, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C-C WuL Y Sheen
Nov 3, 2009·FEMS Immunology and Medical Microbiology·Kusum HarjaiSukhvinder Singh
Apr 15, 2016·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Anastasia KuttSunita Vohra
Aug 21, 2007·Phytotherapy Research : PTR·Wen-hu LiuMei-chin Yin
Jun 16, 2007·Organic & Biomolecular Chemistry·Ute MünchbergClaus Jacob
Mar 10, 2004·Physiological Measurement·Sharon ZlochiverXue-Tao Shi
Feb 6, 2020·Experimental and Therapeutic Medicine·Masato NakamotoYukihiro Kodera
May 13, 2006·Molecular and Cellular Biochemistry·Arumugam ArunkumarJagedeesan Arunakaran
Aug 17, 2021·Frontiers in Microbiology·Sushma Bagde BhatwalkarRajaneesh Anupam
Aug 23, 2021·Molecular and Cellular Biochemistry·Salim M A BastakiE Adeghate
Nov 17, 2021·Biomacromolecules·Romy A DopTom Hasell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.