Abstract
Understanding which antimicrobial agents are likely to be active against Gram-negative bacilli can guide selection of antimicrobials for empirical therapy as mechanistic rapid diagnostics are adopted. In this study, we determined the MICs of a novel β-lactam-β-lactamase inhibitor combination, imipenem-relebactam, along with ceftolozane-tazobactam, imipenem, ertapenem, meropenem, ceftriaxone, and cefepime, against 282 drug-resistant isolates of Gram-negative bacilli. For isolates harboring blaKPC (n = 110), the addition of relebactam to imipenem lowered the MIC50/MIC90 from 16/>128 μg/ml for imipenem alone to 0.25/1 μg/ml. For isolates harboring blaCTX-M (n = 48), the MIC50/MIC90 of ceftolozane-tazobactam were 0.5/16 μg/ml (83% susceptible). For isolates harboring blaCMY-2 (n = 17), the MIC50/MIC90 of ceftolozane-tazobactam were 4/8 μg/ml (47% susceptible). Imipenem-relebactam was active against most KPC-producing (but not NDM- or IMP-producing) Enterobacteriaceae and is an encouraging addition to the present antibiotic repertoire.
References
Mar 1, 1988·Antimicrobial Agents and Chemotherapy·W J Brown
Mar 4, 2000·Journal of Clinical Microbiology·C BornetC Bollet
Mar 18, 2000·Antimicrobial Agents and Chemotherapy·L PoirelP Nordmann
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Jul 17, 2007·Clinical Microbiology Reviews·Anne Marie Queenan, Karen Bush
Dec 26, 2008·Journal of Clinical Microbiology·F J L RobbertsR Patel
Jun 6, 2009·Journal of Clinical Microbiology·Peggy C KohnerRobin Patel
Jan 25, 2013·Journal of Clinical Microbiology·Scott A CunninghamRobin Patel
Mar 16, 2013·International Journal of Medical Microbiology : IJMM·Marco Maria D'AndreaGian Maria Rossolini
Apr 6, 2013·Journal of Medical Microbiology·Jeanette W P TeoRaymond T P Lin
May 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M N D BalmJ W P Teo
May 23, 2013·The Journal of Antimicrobial Chemotherapy·David M LivermoreShazad Mushtaq
Jan 1, 2012·Western Pacific Surveillance and Response Journal : WPSAR·Jeanette TeoRaymond Lin
Sep 11, 2013·Pathology·Tse Hsien KohEng Eong Ooi
Oct 9, 2013·Antimicrobial Agents and Chemotherapy·David J FarrellRonald N Jones
Oct 31, 2014·New Microbes and New Infections·J W P TeoK T Hsien
Dec 23, 2014·Expert Opinion on Pharmacotherapy·Christian Eckmann, Joseph Solomkin
Jan 7, 2015·Saudi Journal of Biological Sciences·Sibhghatulla ShaikhMohammad Amjad Kamal
Mar 7, 2015·Mayo Clinic Proceedings·Shawn VasooPritish K Tosh
May 28, 2015·Antimicrobial Agents and Chemotherapy·Amabel LapueblaJohn Quale
Jun 18, 2015·Drug Design, Development and Therapy·Marion J Skalweit
Jul 6, 2015·International Journal of Antimicrobial Agents·Jordan L LiscioElizabeth B Hirsch
Jul 15, 2015·The Annals of Pharmacotherapy·Allana J SucherMatthew Fete
Sep 24, 2015·Antimicrobial Agents and Chemotherapy·Shawn VasooRobin Patel
Oct 27, 2015·International Journal of Antimicrobial Agents·Karen Bush
Feb 19, 2016·Journal of Clinical Microbiology·Scott A CunninghamRobin Patel
Mar 24, 2016·International Journal of Antimicrobial Agents·Ling-Shan SyuePo-Ren Hsueh
Jun 4, 2016·International Journal of Antimicrobial Agents·Monica PavezElsa Masae Mamizuka
Jun 10, 2016·Therapeutics and Clinical Risk Management·Stephanie E GiancolaElizabeth B Hirsch
Jun 23, 2016·Cold Spring Harbor Perspectives in Medicine·Karen Bush, Patricia A Bradford
Citations
Jun 21, 2019·The Journal of Antimicrobial Chemotherapy·Alan R NoelAlasdair P MacGowan
Aug 1, 2019·Pathogens and Disease·Brandon Kulengowski, David S Burgess
Sep 11, 2019·Expert Opinion on Pharmacotherapy·Krisztina M Papp-Wallace
Nov 13, 2019·Antimicrobial Agents and Chemotherapy·Wim A FleischmannRobin Patel
Jan 15, 2020·Current Infectious Disease Reports·Mandee NovalEmily Heil
Feb 16, 2020·Pharmacotherapy·Jordan R SmithKimberly C Claeys
Aug 21, 2020·Expert Review of Anti-infective Therapy·Nicolette TheriaultChristian E Sandrock
Jul 31, 2020·Journal of Clinical Microbiology·Hanna HakvoortRobin Patel
Apr 23, 2019·Expert Review of Anti-infective Therapy·Georgios L VoulgarisMatthew E Falagas
Nov 21, 2019·MSystems·Jessica Y El KhouryMarc Ouellette
Dec 4, 2020·Infection and Drug Resistance·Toni A Campanella, Jason C Gallagher
Nov 13, 2020·Clinical Microbiology Reviews·Dafna YahavLeonard Leibovici
Feb 26, 2021·Drugs·Young-A Heo
Mar 9, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Tsung-Ying YangPo-Liang Lu
Mar 8, 2021·BMC Microbiology·James A KarlowskyDaniel F Sahm
Mar 24, 2021·Antimicrobial Agents and Chemotherapy·Viivi H A HirvonenMarc W van der Kamp
Jun 15, 2021·Expert Opinion on Pharmacotherapy·Júlia Sellarès-NadalBenito Almirante
Aug 10, 2021·Antimicrobial Agents and Chemotherapy·Sam Horwich-ScholefieldMark Pandori