PMID: 2507220May 1, 1989Paper

In vitro activity of lomefloxacin against multiply resistant Pseudomonas aeruginosa, Enterobacter cloacae, and Staphylococcus epidermidis

Diagnostic Microbiology and Infectious Disease
C A DiVincenzoF R Venezio

Abstract

Lomefloxacin is a promising new difluorinated quinolone with good antimicrobial activity and favorable pharmacokinetic properties. The in vitro activity of lomefloxacin was compared to other quinolones, expanded spectrum beta-lactams, and gentamicin. The lomefloxacin MIC90 against multiply resistant strains of P. aeruginosa was 4 mcg/ml, comparable to norfloxacin and ofloxacin. Lomefloxacin was also active against methicillin-resistant S. epidermidis and JK corynebacteria. The role of lomefloxacin in the treatment of infections caused by multiresistant organisms remains to be determined in clinical trials.

References

Oct 1, 1988·Antimicrobial Agents and Chemotherapy·P J MorrisonR L Kunka
Dec 1, 1988·The Journal of Antimicrobial Chemotherapy·R FinchR Pilkington
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·T HiroseS Mitsuhashi

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Citations

Jan 30, 2020·Current Drug Targets·Usha K RoutGaurav R Dwivedi

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