PMID: 9554174Apr 29, 1998Paper

In vitro activity of LY333328 against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus, and penicillin-resistant Streptococcus pneumoniae

Diagnostic Microbiology and Infectious Disease
R PatelJ M Steckelberg

Abstract

We report the activity of LY333328 against 35 clinical isolates of vancomycin-resistant enterococci (including organisms carrying the vanA, vanB, vanC-1, and vanC-2/3 genes, as determined by PCR), 33 clinical isolates of methicillin-resistant S. aureus, and 29 clinical isolates of high-level penicillin-resistant S. pneumoniae. All isolates of vancomycin-resistant enterococci were inhibited by 2 micrograms/mL LY333328, and 8 micrograms/mL LY333328 was bactericidal against all isolates tested. All isolates of methicillin-resistant S. aureus were inhibited by 1 microgram/mL LY333328, and 4 micrograms/mL LY333328 was bactericidal against all methicillin-resistant S. aureus isolates tested. All isolates of penicillin-resistant S. pneumoniae were inhibited by < 0.125 microgram/mL LY333328, and 0.25 microgram/mL LY333328 was bactericidal against all S. pneumoniae isolates tested. LY333328 is a promising new glycopeptide antimicrobial agent.

References

Jul 1, 1995·Antimicrobial Agents and Chemotherapy·D F SahmS Handwerger
May 1, 1993·The Journal of Infectious Diseases·M K HaydenD F Sahm

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Citations

Feb 27, 2008·Antimicrobial Agents and Chemotherapy·Francis F ArhinGregory Moeck
Feb 13, 2001·Antimicrobial Agents and Chemotherapy·R PatelJ M Steckelberg
Oct 12, 2000·Clinical Microbiology Reviews·Y CetinkayaC G Mayhall
Dec 5, 2008·Expert Review of Anti-infective Therapy·Peter K Linden
Nov 1, 2009·Expert Review of Clinical Pharmacology·Knut Ohlsen
Mar 22, 2006·Expert Opinion on Investigational Drugs·Kristina E WardKerry L LaPlante
Jan 31, 2003·Expert Opinion on Investigational Drugs·Neil Woodford
Jan 31, 2008·Expert Opinion on Investigational Drugs·Garyphallia Poulakou, Helen Giamarellou
Jul 24, 2013·Diagnostic Microbiology and Infectious Disease·Xia ZhangXiancai Rao
Feb 15, 2003·FEMS Microbiology Reviews·Norris E Allen, Thalia I Nicas
Feb 23, 2000·Mayo Clinic Proceedings·A Virk, J M Steckelberg
Nov 9, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ryan J Attwood, Kerry L LaPlante
Feb 14, 2019·Journal of Orthopaedic Surgery and Research·Suzannah M Schmidt-MalanRobin Patel

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